Goodnight S H
Oregon Health Sciences University, Portland 97201.
Semin Thromb Hemost. 1988 Jul;14(3):285-9. doi: 10.1055/s-2007-1002790.
Our understanding of the effects of fish oil and the omega-3 fatty acids on platelet and vascular composition and function has increased substantially in the last decade. It is clear that the omega-3 fatty acids found in marine oils may be incorporated into the cell membranes of platelets and endothelial cells and that they may alter the synthesis of prostaglandins. Platelet function is modestly inhibited, and platelet and vascular interactions appear to be modified in humans. It is far too early to advocate widespread prophylactic or therapeutic use of dietary fish oils to prevent or reduce atherosclerotic cardiovascular disease. Additional studies are needed, especially in respect to the prevention or regression of atherosclerosis, inhibition of arterial thrombosis, and long-term toxicity.
在过去十年中，我们对鱼油和ω-3脂肪酸对血小板及血管组成与功能的影响的理解有了大幅提升。很明显，海洋油中发现的ω-3脂肪酸可能会融入血小板和内皮细胞的细胞膜，并且它们可能会改变前列腺素的合成。血小板功能受到适度抑制，而且在人类中血小板与血管的相互作用似乎也发生了改变。现在提倡广泛预防性或治疗性使用膳食鱼油来预防或减少动脉粥样硬化性心血管疾病还为时过早。还需要进行更多研究，尤其是关于动脉粥样硬化的预防或消退、动脉血栓形成的抑制以及长期毒性方面的研究。
