Luo M, Rossmann M G, Palmenberg A C
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
Virology. 1988 Oct;166(2):503-14. doi: 10.1016/0042-6822(88)90521-1.
Atomic models of foot-and-mouth disease virus and hepatitis A virus have been predicted using amino acid sequence alignments with the known structures of Mengo virus and human rhinovirus 14. The structural models are consistent with results of biochemical and immunological studies. The two viruses appear to have surface features exceedingly different than those of other picornaviruses. They also have large hydrophobic cavities within VP1 suggesting that it may be possible to inhibit their infectivity with suitably designed antiviral agents that block uncoating.
利用与门戈病毒和人鼻病毒14已知结构的氨基酸序列比对，预测了口蹄疫病毒和甲型肝炎病毒的原子模型。这些结构模型与生化和免疫学研究结果一致。这两种病毒的表面特征似乎与其他小核糖核酸病毒极为不同。它们在VP1内也有大的疏水腔，这表明有可能用适当设计的阻断脱壳的抗病毒剂来抑制它们的感染性。
