McCullough K C, Smale C J, Carpenter W C, Crowther J R, Brocchi E, De Simone F
Immunology. 1987 Jan;60(1):75-82.
A mechanism of neutralization of virus infectivity by antibody is described and related to the immune defences in vivo. The interaction of a particular monoclonal antibody with homologous foot-and-mouth disease virus alters the conformation of the virions to permit penetration of staining reagents. A consequence of this structural alteration is that the RNA genome becomes susceptible to dissociation from the capsid proteins. This mechanism of virus neutralization is irreversible and therefore provides an effective in vivo defence measure against virus attack, complementing the enhanced phagocytosis effected through opsonization of virions. With viruses that can replicate in phagocytes, such a mechanism of virus neutralization could provide a major 'specific' immunological defence against virus invasion.
本文描述了抗体中和病毒感染性的机制，并将其与体内免疫防御相关联。一种特定的单克隆抗体与同源口蹄疫病毒的相互作用会改变病毒粒子的构象，从而使染色试剂能够穿透。这种结构改变的一个结果是RNA基因组变得易于从衣壳蛋白上解离。这种病毒中和机制是不可逆的，因此为抵御病毒攻击提供了一种有效的体内防御措施，补充了通过病毒粒子调理作用实现的增强吞噬作用。对于能够在吞噬细胞中复制的病毒，这种病毒中和机制可以提供一种主要的针对病毒入侵的“特异性”免疫防御。
