• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Identification of HPV 16 early genes retained in cervical carcinomas.

作者信息

Wilczynski S P, Pearlman L, Walker J

机构信息

Department of Pathology, University of California, Irvine 92717.

出版信息

Virology. 1988 Oct;166(2):624-7. doi: 10.1016/0042-6822(88)90539-9.

DOI:10.1016/0042-6822(88)90539-9
PMID:2845667
Abstract

Fourteen cervical carcinomas containing HPV 16 DNA were analyzed by Southern blot hybridization with probes for HPV 16 E1, E2, E6, and E7 genes. All tumors hybridized with the E7 gene-specific probe while 2 tumors appear to be deleted in the E6 region. In 11 of the 14 tumors, deletions and/or rearrangements were detected in the E1 and E2 regions. Only one of the 14 tumors had a prototype HPV 16 restriction. Our findings that the E7 gene is the most conserved region of HPV 16 in cervical carcinomas suggest it may play a role in the maintenance of the malignant state.

摘要

相似文献

1
Identification of HPV 16 early genes retained in cervical carcinomas.
Virology. 1988 Oct;166(2):624-7. doi: 10.1016/0042-6822(88)90539-9.
2
Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames.人乳头瘤病毒16型整合入宫颈癌的细胞DNA：E2基因的优先缺失以及长控制区和E6/E7开放阅读框的恒定保留。
Virology. 1987 Nov;161(1):259-61. doi: 10.1016/0042-6822(87)90195-4.
3
Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.人乳头瘤病毒感染阳性和阴性的原发性宫颈癌中p53基因的改变
Cancer Res. 1992 Oct 1;52(19):5323-8.
4
A research for the relationship between human papillomavirus and human uterine cervical carcinoma. I. The identification of viral genome and subgenomic sequences in biopsies of Chinese patients.一项关于人乳头瘤病毒与人类子宫颈癌关系的研究。I. 中国患者活检样本中病毒基因组和亚基因组序列的鉴定。
J Cancer Res Clin Oncol. 1991;117(5):454-9. doi: 10.1007/BF01612767.
5
Episomal HPV 16 DNA isolated from a cervical carcinoma presents a partial duplication of the early region.从宫颈癌中分离出的游离型人乳头瘤病毒16型DNA呈现早期区域的部分重复。
Virus Res. 1989 Sep;14(1):49-55. doi: 10.1016/0168-1702(89)90068-3.
6
[Molecular biologic study on the carcinogenesis of HPV in uterine cervical cancer and related lesions--analysis of HPV types 16, 18 E6/E7 gene mRNA].[人乳头瘤病毒（HPV）在子宫颈癌及相关病变中致癌作用的分子生物学研究——HPV16、18型E6/E7基因mRNA分析]
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Aug;42(8):823-33.
7
Expression of human papillomavirus types 16 and 18 DNA sequences in cervical carcinoma cell lines.人乳头瘤病毒16型和18型DNA序列在宫颈癌细胞系中的表达。
J Med Virol. 1988 Oct;26(2):185-95. doi: 10.1002/jmv.1890260210.
8
Conservation of HPV-16 E6/E7 ORF sequences in a cervical carcinoma.人乳头瘤病毒16型E6/E7开放阅读框序列在宫颈癌中的保守性
J Med Virol. 1992 Jun;37(2):99-107. doi: 10.1002/jmv.1890370205.
9
The integration of HPV-18 DNA in cervical carcinoma.人乳头瘤病毒18型（HPV - 18）DNA在宫颈癌中的整合。
Mol Pathol. 1999 Oct;52(5):275-82. doi: 10.1136/mp.52.5.275.
10
Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas.人乳头瘤病毒16型和18型序列在源自宫颈癌的细胞系中的整合与转录
J Gen Virol. 1987 Feb;68 ( Pt 2):583-91. doi: 10.1099/0022-1317-68-2-583.

引用本文的文献

1
Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma.宫颈腺鳞癌中HPV 16和18的患病率、病毒载量及身体状况
Virchows Arch. 2009 Sep;455(3):253-9. doi: 10.1007/s00428-009-0823-x.
2
The integration of HPV-18 DNA in cervical carcinoma.人乳头瘤病毒18型（HPV - 18）DNA在宫颈癌中的整合。
Mol Pathol. 1999 Oct;52(5):275-82. doi: 10.1136/mp.52.5.275.
3
Genomic organization of human papillomavirus type 18 in cervical cancer specimens.宫颈癌标本中18型人乳头瘤病毒的基因组结构
Jpn J Cancer Res. 1996 Mar;87(3):263-8. doi: 10.1111/j.1349-7006.1996.tb00215.x.
4
Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequences.宫颈癌中整合型人乳头瘤病毒16型DNA的分析：病毒序列与细胞侧翼序列的扩增
J Virol. 1990 Feb;64(2):813-21. doi: 10.1128/JVI.64.2.813-821.1990.
5
The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties.非致癌性人乳头瘤病毒6b型（HPV - 6b）和致癌性HPV - 16的E7蛋白在视网膜母细胞瘤蛋白结合及其他特性方面存在差异。
J Virol. 1990 Feb;64(2):723-30. doi: 10.1128/JVI.64.2.723-730.1990.
6
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells.人乳头瘤病毒16型的E7基因足以使人上皮细胞永生化。
J Virol. 1991 Jan;65(1):473-8. doi: 10.1128/JVI.65.1.473-478.1991.
7
Testing for human papillomavirus: basic pathobiology of infection, methodologies, and implications for clinical use.人乳头瘤病毒检测：感染的基本病理生物学、方法及临床应用意义
Yale J Biol Med. 1991 Mar-Apr;64(2):113-25.
8
The incidence of HPV in a Swedish series of invasive cervical carcinoma.瑞典一系列浸润性宫颈癌中HPV的发病率。
Med Oncol Tumor Pharmacother. 1992;9(3):113-7. doi: 10.1007/BF02987743.
9
Transcriptional enhancer factor (TEF)-1 and its cell-specific co-activator activate human papillomavirus-16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells.转录增强因子（TEF）-1及其细胞特异性共激活因子可激活角质形成细胞和宫颈癌细胞中人乳头瘤病毒16型E6和E7癌基因的转录。
EMBO J. 1992 Jun;11(6):2271-81. doi: 10.1002/j.1460-2075.1992.tb05286.x.