人乳头瘤病毒检测：感染的基本病理生物学、方法及临床应用意义
Testing for human papillomavirus: basic pathobiology of infection, methodologies, and implications for clinical use.
作者信息
Wilbur D C, Stoler M H
机构信息
Department of Pathology, University of Connecticut Health Center, Farmington.
出版信息
Yale J Biol Med. 1991 Mar-Apr;64(2):113-25.
New molecular biological evidence has recently emerged, strongly implicating the human papillomavirus (HPV) as playing an etiologic role in the development of neoplasias of the genital tract. As technologies advance, the ability to test for the presence of HPV has become simpler, more reliable, and less expensive. A great deal of controversy has arisen regarding the effective and proper utilization of these new tests in the management of HPV infections. This review will detail the new evidence implicating the putative role of HPV in neoplasia and the current methodologies available for assessing the presence of HPV in clinical samples and will describe the current controversy surrounding their utilization.
最近出现了新的分子生物学证据，有力地表明人乳头瘤病毒（HPV）在生殖道肿瘤的发生中起病因学作用。随着技术的进步，检测HPV存在的能力变得更简单、更可靠且成本更低。关于这些新检测方法在HPV感染管理中的有效和合理应用，已经出现了大量争议。本综述将详细阐述表明HPV在肿瘤形成中假定作用的新证据，以及目前可用于评估临床样本中HPV存在的方法，并将描述围绕其应用的当前争议。
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