艾滋病毒感染者的大麻使用、药物管理与依从性
Cannabis Use, Medication Management and Adherence Among Persons Living with HIV.
作者信息
Vidot Denise C, Lerner Brenda, Gonzalez Raul
机构信息
School of Nursing and Health Sciences, University of Miami, 5030 Brunson Ave, Coral Gables, FL, 33146, USA.
Department of Psychology, Center for Children and Families, Florida International University, Miami, FL, USA.
出版信息
AIDS Behav. 2017 Jul;21(7):2005-2013. doi: 10.1007/s10461-017-1782-x.
Abstract
Cannabis is used to relieve nausea, trigger weight gain, and reduce pain among adults living with HIV; however, the relationship between its use and medication adherence and management is unclear. Participants (N = 107) were from an ongoing cohort study of community-dwelling HIV+ adults, stratified by cannabis (CB) use: HIV+/CB+ (n = 41) and HIV+/CB- (n = 66). CB+ participants either tested positive in a urine toxicology screen for THC or had a self-reported history of regular and recent use. HIV-status was provided by physician results and/or biomarker assessment. Adherence was measured via the Morisky scale and medication management was assessed via the Medication Management Test-Revised. After adjusting for gender, we found no association between cannabis use group and adherence nor medication management. The amount of cannabis used was also not associated with measures of adherence and management. Preliminary findings suggest that cannabis use may not adversely influence medication adherence/management among adults living with HIV.
摘要
大麻被用于缓解恶心、促进体重增加以及减轻感染艾滋病毒的成年人的疼痛；然而，其使用与药物依从性及管理之间的关系尚不清楚。参与者（N = 107）来自一项正在进行的针对社区居住的艾滋病毒阳性成年人的队列研究，按大麻（CB）使用情况分层：艾滋病毒阳性/大麻使用阳性（n = 41）和艾滋病毒阳性/大麻使用阴性（n = 66）。大麻使用阳性的参与者要么在尿液毒理学筛查中四氢大麻酚检测呈阳性，要么有自我报告的近期经常使用大麻的历史。艾滋病毒感染状况由医生诊断结果和/或生物标志物评估提供。依从性通过莫利斯基量表进行测量，药物管理通过修订后的药物管理测试进行评估。在对性别进行调整后，我们发现大麻使用组与依从性以及药物管理之间均无关联。大麻的使用量也与依从性及管理指标无关。初步研究结果表明，大麻使用可能不会对感染艾滋病毒的成年人的药物依从性/管理产生不利影响。
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2
Combined effects of HIV and marijuana use on neurocognitive functioning and immune status.人类免疫缺陷病毒（HIV）与使用大麻对神经认知功能和免疫状态的综合影响。
AIDS Care. 2016;28(5):628-32. doi: 10.1080/09540121.2015.1124983. Epub 2015 Dec 23.
3
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.医用大麻素：系统评价和荟萃分析。
JAMA. 2015;313(24):2456-73. doi: 10.1001/jama.2015.6358.
4
The moderating effects of cannabis use and decision making on the relationship between conduct disorder and risky sexual behavior.大麻使用和决策对品行障碍与危险性行为之间关系的调节作用。
J Clin Exp Neuropsychol. 2015;37(3):303-15. doi: 10.1080/13803395.2015.1010489. Epub 2015 Apr 1.
5
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6
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8
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9
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