Department of Physiscal Chemistry - Interfacial Phenomena, Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland.
Department of Physiscal Chemistry - Interfacial Phenomena, Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland.
Adv Colloid Interface Sci. 2017 Nov;249:321-330. doi: 10.1016/j.cis.2017.04.007. Epub 2017 Apr 20.
The current need for long lasting implants and bone substitutes characterized by biocompatibility, bioactivity and mechanical properties, without the immune rejection is a great challenge for scientists. These bone substitute structures should be prepared for individual patients with all details controlled on the micrometer level. Similarly, nontoxic, biocompatible targeted drug delivery systems which allow controlling the rate and time period of the drug delivery and simultaneously eliminating toxic and side effects on the healthy tissues, are of great interest. Extensive attempts have been made to develop a simple, efficient, and green method to form biofunctional scaffolds and implant coatings possessing the above mentioned significant biocompatibility, bioactivity and mechanical strength. Moreover, that could also serve as drug delivery systems. Hydroxyapatite (HA) which is a major mineral component of vertebrate bones and teeth is an excellent material for these purposes. In this literature review the biologically inspired scaffolds, bone substitutes, implants characterized by mechanical strength and biocompatibility, as well the drug delivery systems, based on hydroxyapatite are discussed.
目前，科学家们面临着一个巨大的挑战，即需要开发出具有生物相容性、生物活性和机械性能、且不会引起免疫排斥的长效植入物和骨替代品。这些骨替代结构应针对个体患者进行制备，所有细节都应在微米级水平上进行控制。同样，无毒、生物相容的靶向药物输送系统也引起了人们的极大兴趣，因为它可以控制药物输送的速度和时间，并同时消除对健康组织的毒性和副作用。人们已经进行了广泛的尝试，以开发一种简单、高效和绿色的方法，来形成具有上述显著生物相容性、生物活性和机械强度的生物功能支架和植入物涂层，并且还可以作为药物输送系统。羟基磷灰石（HA）是脊椎动物骨骼和牙齿的主要矿物成分，是满足这些需求的绝佳材料。在这篇文献综述中，讨论了基于羟基磷灰石的具有机械强度和生物相容性的仿生支架、骨替代品和植入物，以及药物输送系统。
