Gupta Komal, Kaushik Niranjan, Sharma Vikram, Singh Amit
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India.
Galgotias College of Pharmacy, Greater Noida, India.
Odontology. 2025 Apr 10. doi: 10.1007/s10266-025-01096-3.
The increasing relevance of biomaterials in medical curements and the care of aging populations has led to significant advancements in the development and modification of these materials. Hydroxyapatite (HAp), a biocompatible ceramic that mimics the composition of bone mineral, stands out for its remarkable abilities. Its stability in body fluids and ability to integrate with bone without causing toxicity or inflammation made it a prime candidate for biomedical utilization, particularly in odontology and orthopedics. Dental implants, which necessitate a strong interface with the jawbone to effectively support prosthetic devices, are enhanced by coatings of calcium phosphate-based materials like HAp. This enhances osseointegration, ensuring a strong bond and longevity of the implant. HAp may be synthesized both synthetically and from natural sources like mammalian bones, marine shells, and plants, each offering unique trace elements that improve its bioactivity. The synthesis of HAp involves differential technique, including chemical precipitation, and hydrothermal techniques, each impacting the final abilities of the material. The use of natural sources is especially promising, providing a sustainable, cost-effective alternative that retains essential biocompatibility. Hence, this article aims to explore the synthesis, properties, and biomedical applications of hydroxyapatite (HAp), with a special emphasis on its role in improving the performance and durability of dental implants. It also addresses the challenges in manufacturing and biocompatibility, offering insights into future advancements in this field. By addressing current challenges in manufacturing and biocompatibility, HAp paves the way for more effective and long-lasting dental treatments.
生物材料在医疗治疗和老龄人口护理中的相关性日益增加,促使这些材料的开发和改性取得了重大进展。羟基磷灰石(HAp)是一种模仿骨矿物质成分的生物相容性陶瓷,因其卓越的性能而脱颖而出。它在体液中的稳定性以及与骨整合而不引起毒性或炎症的能力,使其成为生物医学应用的首选材料,特别是在牙科学和矫形外科学领域。牙科植入物需要与颌骨形成牢固的界面以有效支撑修复装置,而HAp等磷酸钙基材料涂层可增强植入物性能。这增强了骨整合,确保了植入物的牢固结合和长久使用。HAp可以通过合成方法制备,也可以从哺乳动物骨骼、海贝壳和植物等天然来源中提取,每种来源都提供独特的微量元素,可提高其生物活性。HAp的合成涉及不同技术,包括化学沉淀法和水热法,每种方法都会影响材料的最终性能。使用天然来源尤其具有前景,它提供了一种可持续、经济高效的替代方案,同时保留了基本的生物相容性。因此,本文旨在探讨羟基磷灰石(HAp)的合成、性能和生物医学应用,特别强调其在提高牙科植入物性能和耐用性方面的作用。文章还讨论了制造和生物相容性方面的挑战,为该领域的未来进展提供见解。通过应对当前制造和生物相容性方面的挑战,HAp为更有效和持久的牙科治疗铺平了道路。