急性单核细胞白血病。细胞学、组织学、细胞化学、超微结构及细胞遗传学观察

Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations.

作者信息

Brynes R K, Golomb H M, Desser R K, Recant W, Reese C, Rowley J

出版信息

Am J Clin Pathol. 1976 Apr;65(4):471-82. doi: 10.1093/ajcp/65.4.471.

DOI:10.1093/ajcp/65.4.471

PMID:57715

Abstract

A case of acute monocytic leukemia (AMoL) studied by cytologic, histologic, cytochemical, ultrastructural, and cytogenetic technics is reported. The immature monocytes were characterized by strong fluoride-sensitive nonspecific esterase activity. Nuclear irregularity, prominent nucleoli, erythrophagocytosis, and pinocytosis were observed on transmission electron microscopy, whereas broad-based ruffles, similar to those found on normal monocytes, were identified with scanning electron microscopy. Cytogenetic analysis showed an 8/9 translocation and four or five identical 8p- marker chromosomes in most bone marrow cells.

摘要

报告了一例通过细胞学、组织学、细胞化学、超微结构和细胞遗传学技术研究的急性单核细胞白血病（AMoL）病例。未成熟单核细胞的特征是具有强烈的氟敏感非特异性酯酶活性。透射电子显微镜观察到核不规则、明显核仁、红细胞吞噬作用和胞饮作用，而扫描电子显微镜则识别出与正常单核细胞相似的宽基褶皱。细胞遗传学分析显示大多数骨髓细胞中有8/9易位和四或五条相同的8p-标记染色体。

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