Yasuda Shigetaka, Okada Kentaro, Saijo Yusuke
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630-0192, Japan.
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630-0192, Japan; Japan Science and Technology (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi 332-0012, Japan.
Curr Opin Plant Biol. 2017 Aug;38:10-18. doi: 10.1016/j.pbi.2017.04.007. Epub 2017 Apr 28.
Recognition of microbe- and danger-associated molecular patterns (MAMPs and DAMPs, respectively) by pattern recognition receptors (PRRs) is central to innate immunity in both plants and animals. The plant PRRs described to date are all cell surface-localized receptors. According to their ligand-binding ectodomains, each PRR engages a specific coreceptor or adaptor kinase in its signaling complexes to regulate defense signaling. With a focus on the coreceptor RLK BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1) and related SOMATIC EMBRYOGENESIS RECEPTOR KINASEs (SERKs), here we review the increasing inventory of BAK1 partners and their functions in plant immunity. We also discuss the significance of autoimmunity triggered by BAK1/SERK4 disintegration in shaping the strategies for attenuation of PRR signaling by infectious microbes and host plants.
模式识别受体（PRR）对微生物相关分子模式（MAMP）和危险相关分子模式（DAMP）的识别，分别是植物和动物先天免疫的核心。迄今为止所描述的植物PRR都是细胞表面定位的受体。根据其配体结合胞外结构域，每个PRR在其信号复合物中与特定的共受体或衔接激酶结合，以调节防御信号。本文聚焦于共受体RLK BRI1-ASSOCIATED RECEPTOR KINASE1（BAK1）和相关的体细胞胚胎发生受体激酶（SERK），综述了BAK1伙伴的不断增加的清单及其在植物免疫中的功能。我们还讨论了BAK1/SERK4解体引发的自身免疫在塑造传染性微生物和宿主植物减弱PRR信号策略方面的意义。
