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干扰素治疗加重丙型肝炎病毒感染患者的肺动脉高压：多种危险因素之间的致病相互作用

Interferon Therapy Exacerbated Pulmonary Hypertension in a Patient with Hepatitis C Virus Infection: Pathogenic Interplay among Multiple Risk Factors.

作者信息

Tsuchiya Hiromi, Kioka Hidetaka, Ozu Kentaro, Ohtani Tomohito, Yamaguchi Osamu, Yazaki Yoshikazu, Yamauchi-Takihara Keiko, Sakata Yasushi

机构信息

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan.

Department of Cardiovascular Medicine, Saku General Hospital Advanced Care Center, Japan.

出版信息

Intern Med. 2017;56(9):1061-1065. doi: 10.2169/internalmedicine.56.7822. Epub 2017 May 1.

DOI:10.2169/internalmedicine.56.7822
PMID:28458313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5478568/
Abstract

Pulmonary arterial hypertension (PAH) is known to develop as a consequence of multiple genetic and/or non-genetic factors. A 27-year-old woman with chronic hepatitis C virus (HCV) infection developed severe PAH after interferon (IFN) therapy. Although most of the reported clinical courses of IFN-induced PAH are poor despite the discontinuation of IFN, the present patient was successfully treated with a triple combination therapy. In this report, we discuss the crosstalk among chronic HCV infection, IFN therapy, autoimmune disorders, and portal hypertension in the pathogenesis and development of PAH.

摘要

已知肺动脉高压（PAH）是由多种遗传和/或非遗传因素引起的。一名27岁的慢性丙型肝炎病毒（HCV）感染女性在接受干扰素（IFN）治疗后出现了严重的PAH。尽管大多数报告的IFN诱导的PAH临床病程不佳，即使停用IFN后仍如此，但该患者通过三联联合疗法成功治愈。在本报告中，我们讨论了慢性HCV感染、IFN治疗、自身免疫性疾病和门静脉高压在PAH发病机制和发展过程中的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/9ff984ee5a6e/1349-7235-56-1061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/f238724d5ff1/1349-7235-56-1061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/126be3e78710/1349-7235-56-1061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/9ff984ee5a6e/1349-7235-56-1061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/f238724d5ff1/1349-7235-56-1061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/126be3e78710/1349-7235-56-1061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e170/5478568/9ff984ee5a6e/1349-7235-56-1061-g003.jpg

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本文引用的文献

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Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy.慢性丙型肝炎及抗病毒无干扰素治疗期间的免疫系统调节。
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Mol Genet Metab. 2018 Dec;125(4):351-358. doi: 10.1016/j.ymgme.2018.09.004. Epub 2018 Sep 7.
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