环丙沙星诱发急性泛发性脓疱性皮疹。

Ciprofloxacin induced acute generallised exanthematous pustulosis.

作者信息

Foti Caterina, Romita Paolo, Zanframundo Giovanni, Mastrolonardo Mario, Angelini Gianni, Calogiuri Gianfranco, Nettis Eustacchio, Bonamonte Domenico

机构信息

Dermatological Clinic, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

Department of Medical and Surgical Sciences, Unit of Dermatology, University of Foggia, Foggia, Italy.

出版信息

Indian J Pharmacol. 2017 Jan-Feb;49(1):119-120. doi: 10.4103/0253-7613.201014.

DOI:10.4103/0253-7613.201014

PMID:28458435

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351224/

Abstract

Acute generalized exanthematous pustulosis (AGEP) is an uncommon and self-limiting skin rash commonly caused by drugs and is characterized by the acute onset of fever, pustulosis, and neutrophilia from 4 to 10 days after the drug intake. We describe a case of AGEP in a 61-year-old woman that was hospitalized for the acute onset of fever, erythroderma, and pustulosis. Clinical history revealed that she had been treating a bacterial inguinal intertrigo for 4 days with ciprofloxacin 500 mg tablets twice daily and desloratadine 5 mg tablet once daily. To the best of our knowledge, this is the third reported case of AGEP caused by ciprofloxacin, supporting two other previous reports.

摘要

急性泛发性脓疱性皮病（AGEP）是一种罕见的自限性皮疹，通常由药物引起，其特征为在服药后4至10天急性起病，出现发热、脓疱病和中性粒细胞增多。我们报告一例61岁女性的AGEP病例，该患者因急性发热、红皮病和脓疱病入院。临床病史显示，她曾用环丙沙星500毫克片剂每日两次、地氯雷他定5毫克片剂每日一次治疗细菌性腹股沟擦烂4天。据我们所知，这是第三例由环丙沙星引起的AGEP报告病例，支持了之前的另外两份报告。