Kaur Harmanpreet, Bala Ripan, Nagpal Madhu
Department of Obstetrics and Gynecology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.
J Midlife Health. 2017 Jan-Mar;8(1):28-35. doi: 10.4103/jmh.JMH_84_16.
Role of Vitamin D is very well known for the functioning of many body organs. However, its role in the postmenopausal women in relation to various genitourinary disorders has been recognized recently. The main objective of this study was to evaluate role of Vitamin D in vaginal health, prolapse, bladder and bowel function, and bacterial vaginosis (BV).
This was a randomized controlled study in which 200 geriatric female patients of 65-78 years of age divided into two groups comprising study and control group with 100 participants in each. Detailed obstetrical, gynecological, and clinical history was elicited. Detailed examination regarding the prolapse, urinary and bowel functions, and bacterial infections was done followed by follow-up of 3 and 6 months each. Chi-square and independent -test used for data analysis.
Mean modified vaginal health index (MVHI) among patients with pelvic floor diseases was statistically significant with = 0.0472. There was a visible increasing trend in Vitamin D deficiency with increase in time since menopause ( = 0.1193). Patients with pelvic floor disease had mean Vitamin D statistically significant with = 0.0462. With increase in Vitamin D levels, MVHI was found to be better. The association of mean Vitamin D levels among patients with urinary incontinence as compared to controls was significant with = 0.0460. Association of mean Vitamin D levels in patients with fecal incontinence and BV as compared to controls was not statistically significant with = 0.6304 and 0.79, respectively. Low Vitamin D levels were associated with high mean parathyroid hormone (PTH) levels statistically significant with = 0.034. MVHI was found to increase significantly with Vitamin D supplementation at 3 and 6 months' follow-up. There was increase in Vitamin D and calcium levels and fall in serum PTH levels at 3 and 6 months.
Vitamin D levels were associated with a decreased risk of pelvic floor disorders, improved MVHI in women in geriatric age group.
维生素D在许多身体器官的功能运作中所起的作用广为人知。然而，其在绝经后女性与各种泌尿生殖系统疾病方面的作用直到最近才得到认可。本研究的主要目的是评估维生素D在阴道健康、子宫脱垂、膀胱和肠道功能以及细菌性阴道病（BV）方面的作用。
这是一项随机对照研究，200名年龄在65至78岁之间的老年女性患者被分为两组，即研究组和对照组，每组各100名参与者。详细询问了产科、妇科和临床病史。对子宫脱垂、泌尿和肠道功能以及细菌感染进行了详细检查，随后分别进行了3个月和6个月的随访。采用卡方检验和独立样本t检验进行数据分析。
盆底疾病患者的平均改良阴道健康指数（MVHI）具有统计学意义，P = 0.0472。随着绝经时间的增加，维生素D缺乏呈明显上升趋势（P = 0.1193）。盆底疾病患者的平均维生素D水平具有统计学意义，P = 0.0462。随着维生素D水平的升高，MVHI情况更佳。与对照组相比，尿失禁患者的平均维生素D水平具有显著相关性，P = 0.0460。与对照组相比，粪失禁患者和BV患者的平均维生素D水平的相关性无统计学意义，P分别为0.6304和0.79。低维生素D水平与高平均甲状旁腺激素（PTH）水平相关，具有统计学意义，P = 0.034。在3个月和6个月的随访中，补充维生素D后MVHI显著增加。在3个月和6个月时，维生素D和钙水平升高，血清PTH水平下降。
维生素D水平与老年女性盆底疾病风险降低相关，可改善其MVHI。
