Haugh Matthew G, Heilshorn Sarah C
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Dublin, Ireland.
Curr Opin Solid State Mater Sci. 2016 Aug;20(4):171-179. doi: 10.1016/j.cossms.2016.04.001. Epub 2016 May 6.
The role of substrate mechanics in guiding mesenchymal stem cell (MSC) fate has been the focus of much research over the last decade. More recently, the complex interplay between substrate mechanics and other material properties such as ligand chemistry and substrate degradability to regulate MSC differentiation has begun to be elucidated. Additionally, there are several changes in the presentation of these material properties as the dimensionality is altered from two- to three-dimensional substrates, which may fundamentally alter our understanding of substrate-induced mechanotransduction processes. In this review, an overview of recent findings that highlight the material properties that are important in guiding MSC fate decisions is presented, with a focus on underlining gaps in our existing knowledge and proposing potential directions for future research.
在过去十年中，底物力学在引导间充质干细胞（MSC）命运方面的作用一直是众多研究的焦点。最近，底物力学与其他材料特性（如配体化学和底物可降解性）之间复杂的相互作用对MSC分化的调节作用已开始得到阐明。此外，随着维度从二维底物转变为三维底物，这些材料特性的表现会发生一些变化，这可能会从根本上改变我们对底物诱导的机械转导过程的理解。在这篇综述中，我们概述了近期的研究发现，这些发现突出了在引导MSC命运决定中重要的材料特性，重点是强调我们现有知识中的空白，并提出未来研究的潜在方向。
