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具有仿生微环境的载干细胞水凝胶用于骨软骨修复的研究进展

Advances of Stem Cell-Laden Hydrogels With Biomimetic Microenvironment for Osteochondral Repair.

作者信息

Xu Bingbing, Ye Jing, Yuan Fu-Zhen, Zhang Ji-Ying, Chen You-Rong, Fan Bao-Shi, Jiang Dong, Jiang Wen-Bo, Wang Xing, Yu Jia-Kuo

机构信息

Knee Surgery Department of the Institute of Sports Medicine, Peking University Third Hospital, Beijing, China.

School of Clinical Medicine, Weifang Medical University, Weifang, China.

出版信息

Front Bioeng Biotechnol. 2020 Mar 31;8:247. doi: 10.3389/fbioe.2020.00247. eCollection 2020.

DOI:10.3389/fbioe.2020.00247
PMID:32296692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7136426/
Abstract

Osteochondral damage from trauma or osteoarthritis is a general joint disease that can lead to an increased social and economic burden in the modern society. The inefficiency of osteochondral defects is mainly due to the absence of suitable tissue-engineered substrates promoting tissue regeneration and replacing damaged areas. The hydrogels are becoming a promising kind of biomaterials for tissue regeneration. The biomimetic hydrogel microenvironment can be tightly controlled by modulating a number of biophysical and biochemical properties, including matrix mechanics, degradation, microstructure, cell adhesion, and intercellular interactions. In particular, advances in stem cell-laden hydrogels have offered new ideas for the cell therapy and osteochondral repair. Herein, the aim of this review is to underpin the importance of stem cell-laden hydrogels on promoting the development of osteochondral regeneration, especially in the field of manipulation of biomimetic microenvironment and utilization growth factors with various delivery methods.

摘要

创伤或骨关节炎导致的骨软骨损伤是一种常见的关节疾病，在现代社会中会导致社会和经济负担加重。骨软骨缺损修复效果不佳主要是由于缺乏促进组织再生和替代受损区域的合适组织工程基质。水凝胶正成为一种有前景的用于组织再生的生物材料。通过调节多种生物物理和生化特性，包括基质力学、降解、微观结构、细胞黏附及细胞间相互作用，可以严格控制仿生水凝胶微环境。特别是，含干细胞水凝胶的进展为细胞治疗和骨软骨修复提供了新思路。本文综述的目的是强调含干细胞水凝胶在促进骨软骨再生发展方面的重要性，尤其是在仿生微环境的操控以及利用各种递送方法使用生长因子的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/04a2e30629c1/fbioe-08-00247-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/d503e143f41a/fbioe-08-00247-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/f03b16880924/fbioe-08-00247-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/5854623da7ff/fbioe-08-00247-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/ebad6b649aef/fbioe-08-00247-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/03232e4f08b8/fbioe-08-00247-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/04a2e30629c1/fbioe-08-00247-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/d503e143f41a/fbioe-08-00247-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/a87c743a0040/fbioe-08-00247-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/d00efaf78d5a/fbioe-08-00247-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/f03b16880924/fbioe-08-00247-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/5854623da7ff/fbioe-08-00247-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/ebad6b649aef/fbioe-08-00247-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/03232e4f08b8/fbioe-08-00247-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a42/7136426/04a2e30629c1/fbioe-08-00247-g0008.jpg

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