Jin Hyo Sun, Suh Hyun-Woo, Kim Seong-Jun, Jo Eun-Kyeong
Department of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon 35015, Korea.
Immune Netw. 2017 Apr;17(2):77-88. doi: 10.4110/in.2017.17.2.77. Epub 2017 Apr 20.
Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform regulating innate immune and inflammatory responses. Several mitochondrial proteins and mitochondrial reactive oxygen species have emerged as central players orchestrating the innate immune responses to pathogens and damaging ligands. This review explores our current understanding of the roles played by mitochondria in regulation of innate immunity and inflammatory responses. Recent advances in our understanding of the relationship between autophagy, mitochondria, and inflammasome activation are also briefly discussed. A comprehensive understanding of mitochondrial role in toll-like receptor-mediated innate immune responses and NLRP3 inflammasome complex activation, will facilitate development of novel therapeutics to treat various infectious, inflammatory, and autoimmune disorders.
线粒体是参与能量产生的关键细胞器，充当细胞的代谢中心。最近的研究结果强调了线粒体作为调节先天免疫和炎症反应的关键细胞内信号平台的新作用。几种线粒体蛋白和线粒体活性氧已成为协调对病原体和损伤性配体的先天免疫反应的核心参与者。本文综述探讨了我们目前对线粒体在先天免疫和炎症反应调节中所起作用的理解。还简要讨论了我们对自噬、线粒体和炎性小体激活之间关系理解的最新进展。全面了解线粒体在Toll样受体介导的先天免疫反应和NLRP3炎性小体复合物激活中的作用，将有助于开发治疗各种感染性、炎症性和自身免疫性疾病的新型疗法。
