Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Republic of Korea.
Department of Preventive Medicine, School of Medicine, Kyung Hee University, 02453 Seoul, Korea.
Eur Heart J Cardiovasc Imaging. 2018 Mar 1;19(3):271-278. doi: 10.1093/ehjci/jex091.
The adverse effect of heavy alcohol intake on cardiovascular disease is well established. However, there is only limited information about the risk of subclinical left ventricular (LV) abnormality according to alcohol consumption. Thus, this study was to investigate the association between alcohol consumption and LV functional and structural abnormality.
Study participants were 49 714 Korean adults received echocardiogram as an item of health check-up program. They were stratified into 6 groups according to alcohol consumption; non (life time never drinker), occasional (<1 g/day), light (1-15 g/day), moderate (15-30 g/day), heavy (30-60 g/day), and very heavy (>60 g/day) drinker. Multiple logistic regression analysis was used to assess the odd ratios (ORs) for LV hypertrophy (LVH), increased relative wall thickness (RWT) and impaired LV diastolic (LVD) function with a reference of non-drinker. Additionally, the adjusted mean values of echocardiographic parameters were evaluated to assess LV diastolic function and structure. In logistic regression analysis, very heavy alcohol drinker had the highest adjusted ORs for LVH, increased RWT and impaired LVD function in all participants and male subgroup (P < 0.05). The dose dependent relationship was found between alcohol consumption and impaired LVD function in all participants and gender subgroups. There was no specific pattern of relationship to suggest the favourable effect of light alcohol drinking on heart.
Increased alcohol intake had the adverse effect on LV function and structure. However, potential favourable effect of light alcohol intake was not observed. Prospective studies are required to investigate long-term effect of alcohol consumption on subclinical LV change.
大量饮酒对心血管疾病的不良影响已得到充分证实。然而，关于饮酒与亚临床左心室（LV）异常风险的信息有限。因此，本研究旨在探讨饮酒与 LV 功能和结构异常之间的关系。
研究对象为接受超声心动图作为健康检查项目的 49714 名韩国成年人。他们根据饮酒量分为 6 组：非饮酒者（终生从不饮酒者）、偶尔饮酒者（<1g/天）、轻度饮酒者（1-15g/天）、中度饮酒者（15-30g/天）、重度饮酒者（30-60g/天）和极重度饮酒者（>60g/天）。使用多因素逻辑回归分析评估 LV 肥厚（LVH）、相对壁厚度增加（RWT）和 LV 舒张功能障碍（LVD）的比值比（ORs），以非饮酒者为参照。此外，评估超声心动图参数的调整均值，以评估 LV 舒张功能和结构。在逻辑回归分析中，极重度饮酒者在所有参与者和男性亚组中具有最高的调整后 ORs，用于 LVH、RWT 增加和 LVD 功能障碍（P<0.05）。在所有参与者和性别亚组中，发现了饮酒与 LVD 功能障碍之间存在剂量依赖性关系。没有特定的关系模式表明轻度饮酒对心脏有有利影响。
饮酒量增加对 LV 功能和结构有不良影响。然而，没有观察到轻度饮酒的潜在有利影响。需要进行前瞻性研究，以调查饮酒对亚临床 LV 变化的长期影响。
