母亲和后代暴露于己烯雌酚（DES）的现状。

Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring.

作者信息

Al Jishi Taher, Sergi Consolato

机构信息

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa Faculty of Medicine, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Box 241, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; Stollery Children's Hospital, 8440 112 St, Edmonton, AB, T6G2B7, Canada; Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, PR China.

出版信息

Reprod Toxicol. 2017 Aug;71:71-77. doi: 10.1016/j.reprotox.2017.04.009. Epub 2017 Apr 28.

DOI:10.1016/j.reprotox.2017.04.009

PMID:28461243

Abstract

Diethylstilbestrol (DES) was an orally active estrogen prescribed to the pregnant women to prevent miscarriages. DES is known as a 'biological time bomb' and long-term effects of DES have been recorded in the mothers exposed to DES and their offspring (DES-daughters and DES-sons). Adverse pregnancy outcomes, infertility, cancer, and early menopause have been discovered in women exposed to DES, and some events occur in their offspring and subsequent generations. An increased risk of breast cancer is not limited to the DES-exposed daughters. There is an urgent need to find ways to stop the inheritance cycle of DES and prevent adverse effects of DES in the future generations. The present article reviews the health implications of DES exposure and screening exams currently recommended to DES daughters and their offspring.

摘要

己烯雌酚（DES）是一种口服活性雌激素，曾被开给孕妇以预防流产。DES被称为“生物定时炸弹”，接触过DES的母亲及其后代（DES女儿和DES儿子）身上都记录有DES的长期影响。接触过DES的女性出现了不良妊娠结局、不孕、癌症和过早绝经等情况，其中一些情况也发生在她们的后代及后续几代人身上。患乳腺癌风险增加并不局限于接触过DES的女儿。迫切需要找到方法来阻断DES的遗传循环，并预防其对后代产生不良影响。本文综述了接触DES对健康的影响以及目前建议DES女儿及其后代进行的筛查检查。