Conlon J Leocadia
J. Leocadia Conlon is an assistant professor at Shenandoah University in Winchester, Va., and a women's health specialist at the Free Medical Clinic of Northern Shenandoah Valley in Winchester. The author has disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2017 Feb;30(2):49-52. doi: 10.1097/01.JAA.0000511800.91372.34.
Diethylstilbestrol (DES) is a synthetic estrogen given to pregnant women to prevent miscarriages and preterm labor; the drug was used between 1941 and 1971 in the United States and into the 1980s in other countries. DES exposure is associated with significant long-term health effects, including increased risk for breast cancer, cervical and vaginal clear cell adenocarcinoma, reproductive tract abnormalities, infertility, poor pregnancy outcomes, and early menopause. This article reviews the potential health risks associated with DES exposure, how to assess which patients are at risk, and management recommendations for patients exposed to DES.
己烯雌酚（DES）是一种合成雌激素，曾用于给孕妇预防流产和早产；该药物于1941年至1971年在美国使用，在其他国家一直使用到20世纪80年代。接触DES会带来重大的长期健康影响，包括患乳腺癌、宫颈和阴道透明细胞腺癌的风险增加、生殖道异常、不孕、不良妊娠结局以及过早绝经。本文综述了与接触DES相关的潜在健康风险、如何评估哪些患者处于风险中以及针对接触DES患者的管理建议。
