Fu Shihui, Zhang Youchen, Wang Kaifei, Lei Wenjun, Liu Qiong, Tian Jinwen, Li Bo, Yun Tianyang, Zhao Yali, Lin Jiacai, Li Yunqi, Feng Long
Department of Cardiology, Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, Hainan, China.
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Depress Anxiety. 2025 Aug 28;2025:5565953. doi: 10.1155/da/5565953. eCollection 2025.
Aging is an inevitable process. Chronic pain and late-life depression frequently coexist in older adults. This study was aimed to explore the association between chronic pain and late-life depression in Chinese centenarians and oldest-old adults. According to the list provided by the Department of Civil Affairs, a household survey was conducted on all centenarian and oldest-old adults residing in 18 cities and counties of Hainan Province. The household survey method was used to collect basic information with interview questionnaires, physical examinations, and blood tests conducted by systematically trained doctors and nurses. This study used visual analog scales and numerical rating scale for pain assessment. Geriatric depression scale (GDS) was used for the evaluation of depression. All 1324 older adults had a median age of 91 years, ranging from 80 to 116 years. Among them, 349 older adults (26.4%) have depression, and 507 (38.3%) suffer from chronic pain. Comorbidity rate of chronic pain and late-life depression was 12.6% (167 participants). Furthermore, late-life depression (odds ratio [OR]: 1.591, 95% confidence interval [CI]: 1.218-2.078, and =0.001) was significantly and positively associated with chronic pain in multivariate logistic regression analysis. Chronic pain (OR: 1.581, 95% CI: 1.210-2.067, and =0.001) was significant and positive factor associated with late-life depression in multivariate logistic regression analysis. This study demonstrated that chronic pain and late-life depression are positively associated in Chinese centenarians and oldest-old adults. This suggests that the management of pain should be considered when treating late-life depression in older adults.
衰老是一个不可避免的过程。慢性疼痛和晚年抑郁症在老年人中经常同时存在。本研究旨在探讨中国百岁老人和高龄老人中慢性疼痛与晚年抑郁症之间的关联。根据民政部门提供的名单，对居住在海南省18个市县的所有百岁老人和高龄老人进行了入户调查。采用入户调查方法，通过经过系统培训的医生和护士进行访谈问卷、体格检查和血液检测来收集基本信息。本研究使用视觉模拟量表和数字评定量表进行疼痛评估。采用老年抑郁量表（GDS）评估抑郁情况。所有1324名老年人的年龄中位数为91岁，年龄范围在80至116岁之间。其中，349名老年人（26.4%）患有抑郁症，507名（38.3%）患有慢性疼痛。慢性疼痛和晚年抑郁症的合并患病率为12.6%（167名参与者）。此外，在多因素逻辑回归分析中，晚年抑郁症（优势比[OR]：1.591，95%置信区间[CI]：1.218 - 2.078，P = 0.001）与慢性疼痛显著正相关。在多因素逻辑回归分析中，慢性疼痛（OR：1.581，95% CI：1.210 - 2.067，P = 0.001）是与晚年抑郁症相关的显著正性因素。本研究表明，在中国百岁老人和高龄老人中，慢性疼痛与晚年抑郁症呈正相关。这表明在治疗老年人晚年抑郁症时应考虑疼痛的管理。
