Al Hadidi Moayad, Meng William D, Jumean Khalid, Hawatmeh Amer
Saint Michael's Medical Center, New York Medical College, Newark, New Jersey, USA.
Ann Transl Med. 2017 Mar;5(6):138. doi: 10.21037/atm.2017.03.18.
Syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL syndrome) is described as "headache attributed to noninfectious inflammatory disease" featuring, as its name suggests, headache that mimics migraine in addition to neurologic symptoms such as hemiparesis, hemiparesthesia and dysphagia. We report a case of a 50-year-old African-American female who presented with headache, malaise and subsequent hemiparesis. Despite bearing a close resemblance to an acute episode of meningitis clinically, cerebrospinal fluid (CSF) analysis of the patient was only positive for isolated elevation in white cell count. The patient was diagnosed with HaNDL syndrome which is characterized by transient headache and neurologic deficits with CSF lymphocytosis. While the overall condition often appears substantial, the disease is self-limiting and patients usually recover spontaneously.
伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征（HaNDL综合征）被描述为“归因于非感染性炎症性疾病的头痛”，顾名思义，除了偏瘫、偏身感觉障碍和吞咽困难等神经症状外，还伴有类似偏头痛的头痛。我们报告一例50岁非裔美国女性病例，该患者出现头痛、不适，随后出现偏瘫。尽管临床上与急性脑膜炎发作极为相似，但该患者的脑脊液（CSF）分析仅显示白细胞计数单独升高呈阳性。该患者被诊断为HaNDL综合征，其特征为伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损。虽然总体病情往往看起来很严重，但该疾病具有自限性，患者通常会自发康复。
