Butcher Lindsay D, den Hartog Gerco, Ernst Peter B, Crowe Sheila E
Department of Medicine, University of California, San Diego, La Jolla, California.
Department of Pathology, University of California, San Diego, La Jolla, California.
Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):316-322. doi: 10.1016/j.jcmgh.2017.02.002. eCollection 2017 May.
is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state with continued oxidative stress within the tissue. Reactive oxygen species and reactive nitrogen species produced by the immune and epithelial cells damage the host cells and can result in DNA damage. has evolved to evoke this damaging response while blunting the host's efforts to kill the bacteria. This long-lasting state with inflammation and oxidative stress can result in gastric carcinogenesis. Continued efforts to better understand the bacterium and the host response will serve to prevent or provide improved early diagnosis and treatment of gastric cancer.
是一种革兰氏阴性微需氧菌，可感染胃部，除其他疾病外，还可导致胃癌的发生。宿主无法清除感染会导致组织内持续存在氧化应激的慢性炎症状态。免疫细胞和上皮细胞产生的活性氧和活性氮会损伤宿主细胞，并可能导致DNA损伤。 已经进化到引发这种破坏性反应，同时削弱宿主杀死细菌的努力。这种伴有炎症和氧化应激的持久状态可导致胃癌发生。持续努力更好地了解这种细菌和宿主反应将有助于预防或提供更好的胃癌早期诊断和治疗。
