Martins Estevão B, Miletto I, Marchese L, Gianotti E
Department of Science and Technological Innovation and Nano-SiSTeMI Centre, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy.
Phys Chem Chem Phys. 2016 Apr 7;18(13):9042-52. doi: 10.1039/c6cp00906a.
A highly efficient bifunctional mesoporous silica nanodevice coupling optical imaging with photodynamic therapy (PDT) was successfully prepared by using Rhodamine B as a contrast agent and verteporfin as a photosensitizer. The precise localization and high dispersion of the contrast agent in the nanoparticles is the key point to get higher fluorescence quantum yields with respect to the fluorophore in solution. To obtain this information photoluminescence spectroscopy coupled with fluorescence lifetime measurements was used, due to its high sensitivity. The bifunctional nanodevice showed good performances both in terms of quantum yield of the anchored Rhodamine B (Φ(RhB) = 0.55) and the singlet oxygen delivery efficiency for PDT applications.
通过使用罗丹明B作为造影剂和维替泊芬作为光敏剂，成功制备了一种将光学成像与光动力疗法（PDT）相结合的高效双功能介孔二氧化硅纳米纳米米纳米器件。造影剂在纳米颗粒中的精确定位和高分散性是相对于溶液中的荧光团获得更高荧光量子产率的关键。由于其高灵敏度，采用了结合荧光寿命测量的光致发光光谱来获取该信息。该双功能纳米器件在锚定罗丹明B的量子产率（Φ(RhB)=0.55）和用于PDT应用的单线态氧传递效率方面均表现出良好性能。
