多功能中空介孔硅纳米粒子靶向递送 5-氨基酮戊酸用于光动力皮肤癌治疗。
Targeted delivery of 5-aminolevulinic acid by multifunctional hollow mesoporous silica nanoparticles for photodynamic skin cancer therapy.
机构信息
†Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
‡School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798.
出版信息
ACS Appl Mater Interfaces. 2015 May 27;7(20):10671-6. doi: 10.1021/acsami.5b03087. Epub 2015 May 15.
5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro.
5-氨基酮戊酸（5-ALA）是一种强的光敏剂原卟啉 IX（PphIX）的前体，用于光动力疗法（PDT）。开发能够帮助 5-ALA 绕过亲脂性屏障直接进入癌细胞的合适的递药载体是一个研究重点。通过 PDT 过程，5-ALA 的递药改进对于皮肤癌治疗甚至更为重要。在这项工作中，制备了靶向配体叶酸（FA）功能化的中空介孔硅纳米颗粒（HMSNPs）以递送至 B16F10 皮肤癌细胞用于 PDT 治疗。FA 靶向配体使负载 5-ALA 的 HMSNPs 能够选择性地内吞进入癌细胞。递送至细胞内的 5-ALA 形成的 PphIX 对体外癌细胞表现出高的光细胞毒性。
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