Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab for Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beiyijie 2, Beijing, 100190, China.
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beiyitiao 11, Beijing, 100190, China.
Angew Chem Int Ed Engl. 2018 May 22;57(21):6049-6053. doi: 10.1002/anie.201712996. Epub 2018 Mar 24.
Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. Magnetic mesoporous silica nanoparticles (MMSNs) were cloaked with red blood cell membrane (RBC). This integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. In vivo experiments demonstrate that RBC@MMSNs can avoid immune clearance and achieve magnetic field (MF)-induced high accumulation in a tumor. When light irradiation is applied, singlet oxygen rapidly generates from hypocrellin B (HB)-loaded RBC@MMSN and leads to the necrosis of tumor tissue. Such a RBC-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, MF-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy.
靶向药物输送是一种新兴的技术策略，使纳米颗粒系统能够对肿瘤治疗做出响应。磁性介孔硅纳米颗粒（MMSNs）被红细胞膜（RBC）包裹。这将长循环、光敏剂输送和磁靶向结合起来用于癌症治疗。体内实验表明，RBC@MMSNs 可以避免免疫清除并在肿瘤中实现磁场（MF）诱导的高聚集。当应用光照射时，载有血卟啉单甲醚（HB）的 RBC@MMSN 迅速产生单线态氧，导致肿瘤组织坏死。这种被 RBC 包裹的磁性纳米载体有效地将免疫佐剂、光敏剂输送、MF 辅助靶向光动力治疗结合在一起，为癌症治疗提供了一种创新策略。
