Gastrin receptors in human gastric scirrhous carcinoma.

Specific binding of 125I-labeled gastrin-17 in tumor tissues and gastric mucosa of 11 advanced human gastric carcinoma cases were studied by single-point receptor assay, using 400 pM 125I-labeled gastrin-17. Membrane preparations (800-15,000 g fraction) of the tissues were examined in this study. In 4 of the 5 cases of gastric scirrhous carcinoma (Borrmann type IV), the tumor tissues showed a high degree of specific bindings (1.1-18.2 femtomoles per milligram protein), but in 5 of the 6 cases of Borrmann type II or III, no specific bindings were detected. These findings indicate that gastrin receptor is frequently present in human gastric scirrhous carcinoma.