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金沙萨成年人哮喘的患病率及决定因素

Prevalence and determinants of asthma in adults in Kinshasa.

作者信息

Obel Kabengele Benoit, Ntumba Kayembe Jean Marie, Kalambayi Kayembe Patrick, Zalagile Akilimali Pierre, Kinkodi Kaba Didine, Munogolo Kashongwe Zacharie

机构信息

Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

出版信息

PLoS One. 2017 May 2;12(5):e0176875. doi: 10.1371/journal.pone.0176875. eCollection 2017.

Abstract

BACKGROUND

Epidemiological data on asthma among adults in sub-Saharan Africa are sparse.

OBJECTIVE

To determine the prevalence of and factors associated with asthma among adults in Kinshasa.

METHODS

A previously validated asthma questionnaire was administered to an adult population aged ≥18 years in urban and peri-urban suburbs of Kinshasa. A random stratified multi-stage sampling plan was used to select the study participants. Logistic regression was used to identify factors associated with asthma.

RESULTS

The mean age of respondents was 36.7 (SD 15.36) years, 75% lived in an urban environment, and 57% were women. The prevalence of asthma-ever was 6.9% (95% CI: 5.4-8.4). Among asthmatic patients, intermittent asthma was estimated at 75.7% and severe asthma at 9.3%. Family atopy (OR: 3.97; 95% CI: 2.42-6.50; p<0.001), and the presence of a cat in the house (OR: 1.82; 95% CI: 1.01-3.28; p = 0.045) were associated with self-reported asthma.

CONCLUSION

Asthma is relatively frequent in adults in Kinshasa, a prevalence similar to those reported elsewhere in Africa. Family atopy and the presence of a cat in the house could be the most common determinants to be confirmed with national survey in order to design guidelines for the control of asthma.

摘要

背景

撒哈拉以南非洲地区成年人哮喘的流行病学数据稀少。

目的

确定金沙萨成年人哮喘的患病率及其相关因素。

方法

对金沙萨市区和城郊年龄≥18岁的成年人群进行一份先前验证过的哮喘问卷调查。采用随机分层多阶段抽样方案选取研究参与者。运用逻辑回归分析确定与哮喘相关的因素。

结果

受访者的平均年龄为36.7(标准差15.36)岁,75%生活在城市环境中,57%为女性。曾患哮喘的患病率为6.9%(95%置信区间:5.4 - 8.4)。在哮喘患者中,间歇性哮喘估计为75.7%,重度哮喘为9.3%。家族特应性(比值比:3.97;95%置信区间:2.42 - 6.50;p<0.001)以及家中养猫(比值比:1.82;95%置信区间:1.01 - 3.28;p = 0.045)与自我报告的哮喘相关。

结论

哮喘在金沙萨成年人中较为常见,其患病率与非洲其他地区报告的相似。家族特应性和家中养猫可能是最常见的决定因素,有待通过全国性调查加以证实,以便制定哮喘控制指南。

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