Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong, China.
J Nanobiotechnology. 2022 Jan 4;20(1):18. doi: 10.1186/s12951-021-01235-2.
Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy.
In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T and T weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor.
Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment.
将多模态成像和协同治疗结合在一个平台上可以提高治疗效果和诊断准确性。
本研究通过微乳液法制备了新型的锰掺杂普鲁士蓝纳米粒子（MnPB NPs）。MnPB NPs 在体外和体内均表现出优异的 T1 和 T2 加权磁共振成像（MRI）增强效果。MnPB NPs 在近红外区域的强吸收为光热治疗（PTT）和光声成像性能提供了高抗肿瘤疗效。此外，由于锰的掺杂，MnPB NPs 表现出优异的芬顿反应活性，用于化学动力学治疗（CDT）。体外和体内的有利的三模态成像和芬顿反应增强温和温度光热治疗进一步证实，MnPB NPs 在整合诊断和治疗肿瘤方面具有显著的积极效果。
总的来说，这种具有多模态成像和化学动力学/温和温度光热协同治疗功能的锰掺杂普鲁士蓝纳米平台为肿瘤治疗提供了一种可靠的工具。
