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腹腔镜手术治疗复杂及复发性克罗恩病

Laparoscopic surgery for complex and recurrent Crohn's disease.

作者信息

Sevim Yusuf, Akyol Cihangir, Aytac Erman, Baca Bilgi, Bulut Orhan, Remzi Feza H

机构信息

Yusuf Sevim, Department of General Surgery, Kayseri Training and Research Hospital, Kayseri 38110, Turkey.

出版信息

World J Gastrointest Endosc. 2017 Apr 16;9(4):149-152. doi: 10.4253/wjge.v9.i4.149.

Abstract

Crohn's disease (CD) is a chronic inflammatory disease of digestive tract. Approximately 70% of patients with CD require surgical intervention within 10 years of their initial diagnosis, despite advanced medical treatment alternatives including biologics, immune suppressive drugs and steroids. Refractory to medical treatment in CD patients is the common indication for surgery. Unfortunately, surgery cannot cure the disease. Minimally invasive treatment modalities can be suitable for CD patients due to the benign nature of the disease especially at the time of index surgery. However, laparoscopic management in fistulizing or recurrent disease is controversial. Intractable fibrotic strictures with obstruction, fistulas with abscess formation and hemorrhage are the surgical indications of recurrent CD, which are also complicating laparoscopic treatments. Nevertheless, laparoscopy can be performed in selected CD patients with safety, and may provide better outcomes compared to open surgery. The common complication after laparoscopic intervention is postoperative ileus seems and this may strongly relate excessive manipulation of the bowel during dissection. But additionally, unsuccessful laparoscopic attempts requiring conversion to open surgery have been a major concern due to presumed risk of worse outcomes. However, recent data show that conversions do not to worsen the outcomes of colorectal surgery in experienced hands. In conclusion, laparoscopic treatment modalities in recurrent CD patients have promising outcomes when it is used selectively.

摘要

克罗恩病(CD)是一种消化道慢性炎症性疾病。尽管有包括生物制剂、免疫抑制药物和类固醇在内的先进医疗替代方案,但约70%的CD患者在初次诊断后的10年内仍需要手术干预。CD患者对药物治疗无效是手术的常见指征。不幸的是,手术无法治愈该疾病。由于该疾病的良性性质,尤其是在初次手术时,微创治疗方式可能适用于CD患者。然而,对于瘘管形成或复发性疾病的腹腔镜治疗存在争议。顽固性纤维化狭窄伴梗阻、伴有脓肿形成的瘘管和出血是复发性CD的手术指征,这些也使腹腔镜治疗复杂化。尽管如此,腹腔镜检查可以在选定的CD患者中安全进行,并且与开放手术相比可能提供更好的结果。腹腔镜干预后的常见并发症是术后肠梗阻,这可能与手术解剖过程中对肠道的过度操作密切相关。但此外,由于推测有更差结果的风险,需要转为开放手术的腹腔镜手术失败一直是一个主要问题。然而,最近的数据表明,在经验丰富的医生手中,转为开放手术并不会使结直肠手术的结果恶化。总之,复发性CD患者的腹腔镜治疗方式在选择性使用时具有良好的前景。

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