Krueger G R, Koch B, Ramon A, Ablashi D V, Salahuddin S Z, Josephs S F, Streicher H Z, Gallo R C, Habermann U
Immunopathology Section, University of Cologne, F.R.G.
J Virol Methods. 1988 Sep;21(1-4):125-31. doi: 10.1016/0166-0934(88)90059-6.
Detailed serologic screening showed an antibody prevalence to HBLV (HHV-6) in the general population of 26% if very strict criteria for antibody positivity were applied. Lower and borderline antibody titers yet may be found in up to 63% of the population. Only 17% of these persons have clinical symptoms; in the majority infection remains silent. HHV-6 infection apparently occurs already quite early in life, and initial symptoms can occur, such as short-term high fever, sore throat, local lymphadenopathy and skin rash. Lesions disappear without specific treatment. The frequency of positive antibody tests at higher titers rises in patients with immune deficiency and with atypical lymphoproliferative diseases to 60 and 75%. The rise in antibody titers is associated in patients with immune deficiency by characteristic shifts of blood lymphocyte populations, essentially by increase in immature T-lymphocytes. Highest titers are found in patients with lymphoproliferative syndromes, yet the percentage of atypical lymphoid cells harboring the viral genome is low (about 2% of seropositive patients). Thus it appears, that HBLV, similar to other herpesviruses such as Epstein-Barr virus, usually causes a silent seroconversion, yet may be associated with variable clinical pathology when persisting in an active state. Its pathogenic effect might be rather a cofactor contributing to immune disturbance than overt oncogenicity.
详细的血清学筛查显示，如果采用非常严格的抗体阳性标准，普通人群中人类B淋巴细胞病毒（HHV - 6）抗体阳性率为26%。在高达63%的人群中可能会发现较低和临界抗体滴度。这些人中只有17%有临床症状；大多数感染处于潜伏状态。HHV - 6感染显然在生命早期就已发生，可能出现如短期高热、咽痛、局部淋巴结病和皮疹等初始症状。病变无需特殊治疗即可消失。在免疫缺陷患者和非典型淋巴细胞增生性疾病患者中，较高滴度抗体检测阳性率分别升至60%和75%。免疫缺陷患者抗体滴度升高与血液淋巴细胞群体特征性变化有关，主要是未成熟T淋巴细胞增加。在淋巴细胞增生综合征患者中发现最高滴度，但携带病毒基因组的非典型淋巴细胞百分比很低（血清阳性患者中约为2%）。因此，似乎人类B淋巴细胞病毒与其他疱疹病毒如爱泼斯坦 - 巴尔病毒相似，通常引起潜伏性血清转化，但在持续活跃状态时可能与多种临床病理相关。其致病作用可能更多是导致免疫紊乱的辅助因素，而非明显的致癌性。
