Khazdouz Maryam, Mazidi Mohsen, Ehsaei Mohammad-Reza, Ferns Gordon, Kengne Andre Pascal, Norouzy Abdol-Reza
a Department of Nutrition, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
b State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology , Chinese Academy of Sciences , Chaoyang, Beijing.
J Diet Suppl. 2018 Jan 2;15(1):1-10. doi: 10.1080/19390211.2017.1304486. Epub 2017 May 3.
To determine the effects of zinc supplementation on clinical outcomes of patients with severe head trauma, this double-blind clinical trial randomly allocated 100 patients with severe head trauma, aged between 18 to 65 years, to receive placebo or 120 mg zinc via a nasogastric tube for 15 days. Plasma zinc and copper, 24-hour urinary zinc excretion, Sequential Organ Failure Assessment (SOFA) were assessed on days 1, 7, and 16. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cell (WBC) count were measured on days 1 and 16. Glasgow outcome score (GOS), mortality rate on day 28, and length of stay (LOS) were compared between groups. There were no significant differences in baseline data between groups (all p > .05). Mean plasma zinc concentration was significantly higher in the zinc group than the placebo group on day 7 (119.5 vs. 81.7 µg/dl, p < .001) and day 16 (124.1 vs. 101.1 µg/dl, p < .001). The SOFA, GOS, and inflammation factors were significantly better in the zinc-supplemented group by day 16 (all p < .05). The LOS was shorter (52 vs. 65 days, p = .043) and mortality rate on day 28 was borderline lower (17% vs. 22%, p = .507) in zinc versus placebo groups. Zinc supplementation in the study had favorable effects on GOS, SOFA score, and inflammatory markers in patients with severe head injury.
为了确定补充锌对重度颅脑创伤患者临床结局的影响，这项双盲临床试验将100例年龄在18至65岁之间的重度颅脑创伤患者随机分为两组，分别通过鼻胃管接受安慰剂或120毫克锌，持续15天。在第1、7和16天评估血浆锌和铜、24小时尿锌排泄量、序贯器官衰竭评估（SOFA）。在第1天和第16天测量红细胞沉降率（ESR）、C反应蛋白（CRP）和白细胞（WBC）计数。比较两组之间的格拉斯哥预后评分（GOS）、第28天的死亡率和住院时间（LOS）。两组之间的基线数据无显著差异（所有p>.05）。锌组在第7天（119.5对81.7µg/dl，p<.001）和第16天（124.1对101.1µg/dl，p<.001）的平均血浆锌浓度显著高于安慰剂组。到第16天，补充锌组的SOFA、GOS和炎症因子明显更好（所有p<.05）。锌组与安慰剂组相比，住院时间更短（52天对65天，p=.043），第28天的死亡率略低（17%对22%，p=.507）。该研究中补充锌对重度颅脑损伤患者的GOS、SOFA评分和炎症标志物有良好影响。
