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粗毛紫菀(Forssk.)Less. 和裂叶蚤草(Lam.)DC.地上部分挥发油的化学成分及抗菌活性:两种生长在霍加尔地区的野生菊科草本植物

Chemical Composition and Antimicrobial Activity of Essential Oils from the Aerial Parts of Asteriscus graveolens (Forssk.) Less. and Pulicaria incisa (Lam.) DC.: Two Asteraceae Herbs Growing Wild in the Hoggar.

作者信息

Chaib Faiza, Allali Hocine, Bennaceur Malika, Flamini Guido

机构信息

Laboratoire des Substances Naturelles & Bioactives (LASNABIO), Département de Chimie, Faculté des Sciences, Université Abou Bekr Belkaïd, BP 119, Tlemcen, 13000, Algérie.

Laboratoire de Biochimie Végétale, Département de Biologie, Faculté des Sciences de la Nature et de la Vie, Université Oran1 Ahmed Benbella, Oran, Algérie.

出版信息

Chem Biodivers. 2017 Aug;14(8). doi: 10.1002/cbdv.201700092. Epub 2017 Jul 1.

DOI:10.1002/cbdv.201700092
PMID:28467692
Abstract

In recent years, antimicrobial activities of essential oils have been intensively explored, mainly in researching and developing new antimicrobial agents to overcome microbial resistance. The present study investigates the chemical composition and antimicrobial activities of essential oils obtained from two Asteraceae: Asteriscus graveolens (Forssk.) Less. and Pulicaria incisa (Lam.) DC. Chemical analysis was performed using a combination of capillary GC-FID and GC/MS analytical techniques. The major component of Asteriscus graveolens were cis-chrysanthenyl acetate (31.1%), myrtenyl acetate (15.1%), and kessane (11.5%), while for Pulicaria incisa the main components were chrysanthenone (45.3%) and 2,6-dimethylphenol (12.6%). The oils obtained from the aerial parts were tested against sixteen microbial strains by agar well diffusion technique and dilution methods and showed minimum inhibitory concentrations (MIC) in the range of 19 - 1250 μg/ml. A good antibacterial activity against a common nosocomial pathogen, Acinetobacter baumanniiATCC 19606 was observed, especially from Pulicaria incisa essential oil, with a MIC value up to 19 μg/ml. These results give significant information about the pharmacological activity of these essential oils, which suggest their benefits to human health, having the potential to be used for medical purposes.

摘要

近年来,人们对精油的抗菌活性进行了深入研究,主要集中在研发新型抗菌剂以克服微生物耐药性方面。本研究调查了两种菊科植物:Asteriscus graveolens (Forssk.) Less. 和Pulicaria incisa (Lam.) DC. 所提取精油的化学成分和抗菌活性。采用毛细管气相色谱-氢火焰离子化检测器(GC-FID)和气相色谱-质谱联用(GC/MS)分析技术进行化学分析。Asteriscus graveolens的主要成分是顺式菊烯基乙酸酯(31.1%)、乙酸桃金娘烯酯(15.1%)和克沙烷(11.5%),而Pulicaria incisa的主要成分是菊酮(45.3%)和2,6-二甲基苯酚(12.6%)。通过琼脂扩散法和稀释法对从地上部分提取的精油进行了针对16种微生物菌株的测试,其最低抑菌浓度(MIC)在19 - 1250 μg/ml范围内。观察到对一种常见的医院病原体鲍曼不动杆菌ATCC 19606具有良好的抗菌活性,尤其是Pulicaria incisa精油,其MIC值高达19 μg/ml。这些结果提供了有关这些精油药理活性的重要信息,表明它们对人类健康有益,具有用于医疗目的的潜力。

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