Department of Biology, University of Rochester, Rochester, NY 14627, USA.
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
Cell Metab. 2017 May 2;25(5):991-992. doi: 10.1016/j.cmet.2017.04.022.
DNA-dependent protein kinase (DNA-PK), a central player in DNA double-strand break (DSB) repair, shows emerging roles in metabolic regulation. In this issue of Cell Metabolism, Park et al. (2017) elucidate a molecular mechanism whereby DNA-PK negatively regulates AMPK, contributing to metabolic and fitness decline during aging.
DNA 依赖性蛋白激酶（DNA-PK）是 DNA 双链断裂（DSB）修复的核心参与者，在代谢调节中表现出新兴的作用。在本期《细胞代谢》中，Park 等人（2017）阐明了一种分子机制，即 DNA-PK 负调控 AMPK，导致衰老过程中的代谢和适应性下降。
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