Slattery M L, Sorenson A W, Mahoney A W, French T K, Kritchevsky D, Street J C
Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City 84132.
J Natl Cancer Inst. 1988 Nov 16;80(18):1474-80. doi: 10.1093/jnci/80.18.1474.
How fiber in the diet is related to the development of colon cancer was assessed in a population-based study conducted on 231 cases and 391 controls in Utah between 1979 and 1983. Crude fiber consistently decreased risk associated with colon cancer in both males [odds ratio (OR) = 0.4] and females (OR = 0.5). Dietary fiber, as analyzed by the method of A. S. Bitner, and neutral detergent fiber were not consistently related to colon cancer risk. Of the noncellulose polysaccharides examined, mannose and galactose were protective against cancers in the ascending colon in males (ORs = 0.5 and 0.3, respectively), whereas galactose and uronic acid were protective against cancers in the ascending colon in females (ORs = 0.5). Highest quartiles of intake of fruits and vegetables were also associated with a decreased risk of colon cancer in males (ORs = 0.3 and 0.6, respectively) and in females (ORs = 0.6 and 0.3, respectively) compared with lowest quartile of intake, whereas high intake of grains was not protective.
1979年至1983年间，在犹他州对231例病例和391例对照进行的一项基于人群的研究中，评估了饮食中的纤维与结肠癌发生之间的关系。粗纤维在男性[比值比（OR）=0.4]和女性（OR = 0.5）中均持续降低了与结肠癌相关的风险。采用A.S.比特纳方法分析的膳食纤维和中性洗涤纤维与结肠癌风险之间并无一致的关联。在所检测的非纤维素多糖中，甘露糖和半乳糖对男性升结肠癌具有保护作用（OR分别为0.5和0.3），而半乳糖和糖醛酸对女性升结肠癌具有保护作用（OR = 0.5）。与最低四分位数摄入量相比，水果和蔬菜摄入量最高的四分位数在男性（OR分别为0.3和0.6）和女性（OR分别为0.6和0.3）中也与结肠癌风险降低相关，而高谷物摄入量则无保护作用。
