Farhan Hesso, Kundu Mondira, Ferro-Novick Susan
Institute of Basic Medical Sciences, University of Oslo, 3072 Oslo, Norway.
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Mol Biol Cell. 2017 May 1;28(9):1161-1164. doi: 10.1091/mbc.E16-11-0762.
The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, there is mounting evidence that the secretory and autophagy pathways are intimately linked and that certain regulatory elements are shared between them. Here we highlight the parallels and points of intersection between these two evolutionarily highly conserved and fundamental endomembrane systems. The intersection of these pathways may play an important role in remodeling membranes during cellular stress.
分泌途径和自噬途径可被视为内膜系统的生物合成（即合成代谢）和降解（即分解代谢）分支。类似于新陈代谢中的合成代谢和分解代谢途径，越来越多的证据表明分泌途径和自噬途径紧密相连，并且它们之间共享某些调控元件。在此，我们着重介绍这两个在进化上高度保守且基本的内膜系统之间的相似之处和交叉点。这些途径的交叉点可能在细胞应激期间的膜重塑中发挥重要作用。
