Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of Córdoba, E-14071, Córdoba, Spain.
Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofía Hospital, University of Córdoba, E-14004, Córdoba, Spain.
Sci Rep. 2017 May 3;7(1):1421. doi: 10.1038/s41598-017-01564-z.
Smoking is a crucial factor in respiratory diseases and lung inflammation, which are the reasons for high mortality worldwide. Despite the negative impact that tobacco consumption causes on health, few metabolomics studies have compared the composition of biofluids from smoker and non-smoker individuals. Exhaled breath condensate (EBC) is one of the biofluids less employed for clinical studies despite its non-invasive sampling and the foreseeable relationship between its composition and respiratory diseases. EBC was used in this research as clinical sample to compare three groups of individuals: current smokers (CS), former smokers (FS) and never smokers (NS). Special attention was paid to the cumulative consumption expressed as smoked pack-year. The levels of 12 metabolites found statistically significant among the three groups of individuals were discussed to find an explanation to their altered levels. Significant compounds included monoacylglycerol derivatives, terpenes and other compounds, the presence of which could be associated to the influence of smoking on the qualitative and quantitative composition of the microbiome.
吸烟是呼吸道疾病和肺部炎症的一个关键因素，这些疾病是全球高死亡率的原因。尽管烟草消费对健康有负面影响，但很少有代谢组学研究比较吸烟者和不吸烟者个体的生物流体组成。呼气冷凝物（EBC）是一种用于临床研究的生物流体，尽管它的采样是非侵入性的，而且它的组成与呼吸道疾病之间存在可预见的关系。在这项研究中，EBC 被用作临床样本，比较了三组个体：当前吸烟者（CS）、曾经吸烟者（FS）和从不吸烟者（NS）。特别关注以吸烟包年数表示的累积吸烟量。对三组个体之间存在统计学差异的 12 种代谢物的水平进行了讨论，以找到其水平改变的解释。存在显著差异的化合物包括单酰基甘油衍生物、萜烯和其他化合物，其存在可能与吸烟对微生物组的定性和定量组成的影响有关。
