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微生物群——未来疗法的意外参数。

The Microbiome - The Unscheduled Parameter for Future Therapies.

作者信息

Beule Achim G

机构信息

HNO-Uniklinik Münster.

Klinik und Poliklinik für Hals-Nasen-Ohrenkrankheiten der Universitätsmedizin Greifswald.

出版信息

Laryngorhinootologie. 2018 Mar;97(S 01):S279-S311. doi: 10.1055/s-0043-122301. Epub 2018 Mar 22.

DOI:10.1055/s-0043-122301
PMID:29905360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6541117/
Abstract

The microbiome is defined as the total of cellular microorganisms of baczerial, viral or e. g., parasite origin living on the surface of a body. Within the anatomical areas of otorhinolaryngology, a significant divergence and variance can be demonstrated. For ear, nose, throat, larynx and cutis different interactions of microbiome and common factors like age, diet and live style factors (e. g., smoking) have been detected in recent years. Besides, new insights hint at a passible pathognomic role of the microbiome towards diseases in the ENT area. This review article resumes the present findings of this rapidly devloping scientific area.

摘要

微生物群被定义为生活在身体表面的细菌、病毒或例如寄生虫来源的细胞微生物的总和。在耳鼻喉科的解剖区域内，可以证明存在显著的差异和变化。近年来，在耳、鼻、喉、皮肤等部位，已检测到微生物群与年龄、饮食和生活方式因素（如吸烟）等常见因素之间存在不同的相互作用。此外，新的见解表明微生物群在耳鼻喉科疾病中可能具有病理诊断作用。这篇综述文章总结了这个快速发展的科学领域的当前研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/ba52243eb7a2/10-1055-s-0043-122301-i5045327-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/477795ae7f29/10-1055-s-0043-122301-i5045327-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/57cc9f36af20/10-1055-s-0043-122301-i5045327-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/c84c67cc6bfd/10-1055-s-0043-122301-i5045327-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/2efb124e725b/10-1055-s-0043-122301-i5045327-0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/2cdfed1b9822/10-1055-s-0043-122301-i5045327-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/9946536e3254/10-1055-s-0043-122301-i5045327-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/1ad94eccab45/10-1055-s-0043-122301-i5045327-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/ba52243eb7a2/10-1055-s-0043-122301-i5045327-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/477795ae7f29/10-1055-s-0043-122301-i5045327-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/57cc9f36af20/10-1055-s-0043-122301-i5045327-0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/c84c67cc6bfd/10-1055-s-0043-122301-i5045327-0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/2efb124e725b/10-1055-s-0043-122301-i5045327-0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/2cdfed1b9822/10-1055-s-0043-122301-i5045327-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/9946536e3254/10-1055-s-0043-122301-i5045327-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/1ad94eccab45/10-1055-s-0043-122301-i5045327-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6541117/ba52243eb7a2/10-1055-s-0043-122301-i5045327-0004.jpg

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Front Cell Infect Microbiol. 2017 Oct 11;7:444. doi: 10.3389/fcimb.2017.00444. eCollection 2017.
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Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.短链脂肪酸可改善微生物组驱动的过敏性肺部炎症。
Mucosal Immunol. 2018 May;11(3):785-795. doi: 10.1038/mi.2017.75. Epub 2017 Oct 25.
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Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease.
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Oxid Med Cell Longev. 2019 May 19;2019:7071536. doi: 10.1155/2019/7071536. eCollection 2019.
肠道微生物组成与酒精依赖综合征和酒精性肝病的关联。
Microbiome. 2017 Oct 17;5(1):141. doi: 10.1186/s40168-017-0359-2.
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Time of day and eating behaviors are associated with the composition and function of the human gastrointestinal microbiota.一天中的时间和饮食行为与人类胃肠道微生物群的组成和功能有关。
Am J Clin Nutr. 2017 Nov;106(5):1220-1231. doi: 10.3945/ajcn.117.156380. Epub 2017 Sep 27.
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A broken promise: microbiome differential abundance methods do not control the false discovery rate.违背诺言：微生物组差异丰度方法无法控制假发现率。
Brief Bioinform. 2019 Jan 18;20(1):210-221. doi: 10.1093/bib/bbx104.
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