Karmakar Monita, Pinto Sharrel L, Jordan Timothy R, Mohamed Iman, Holiday-Goodman Monica
School of Population Health, University of Toledo, Toledo, Ohio, USA.
Department of Pharmacy Practice, University of Toledo, Toledo, Ohio, USA.
Breast Cancer (Auckl). 2017 Mar 2;11:1178223417694520. doi: 10.1177/1178223417694520. eCollection 2017.
The purpose of this observational study was to determine if the Protection Motivation Theory could predict and explain adherence to aromatase inhibitor (AI) therapy among breast cancer survivors. Purposive sampling was used to identify 288 survivors who had been prescribed AI therapy. A valid and reliable survey was mailed to survivors. A total of 145 survivors completed the survey. The Morisky scale was used to measure adherence to AI. The survivors reported a mean score of 6.84 (±0.66) on the scale. Nearly 4 in 10 survivors (38%) were non-adherent. Adherence differed by age, marital status, insurance status, income, and presence of co-morbid conditions. Self-efficacy (r=0.485), protection motivation (r=0.310), and Response Efficacy (r=0.206) were positively and significantly correlated with adherence. Response Cost (r=-0.235) was negatively correlated with adherence. The coping appraisal constructs were statistically significant predictors medication adherence (β=0.437) with self-efficacy being the strongest significant predictor of adherence (β = 0.429).
这项观察性研究的目的是确定保护动机理论是否能够预测并解释乳腺癌幸存者对芳香化酶抑制剂（AI）治疗的依从性。采用目的抽样法确定了288名接受AI治疗的幸存者。向幸存者邮寄了一份有效且可靠的调查问卷。共有145名幸存者完成了调查。使用莫利斯基量表来衡量对AI的依从性。幸存者在该量表上的平均得分为6.84（±0.66）。近十分之四的幸存者（38%）未坚持治疗。依从性在年龄、婚姻状况、保险状况、收入和合并症的存在情况方面存在差异。自我效能感（r = 0.485）、保护动机（r = 0.310）和反应效能（r = 0.206）与依从性呈显著正相关。反应成本（r = -0.235）与依从性呈负相关。应对评估结构是药物依从性的统计学显著预测因素（β = 0.437），其中自我效能感是依从性最强的显著预测因素（β = 0.429）。
