Uwaezuoke Samuel N, Eneh Chizoma I, Ndu Ikenna K
Department of Pediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Department of Pediatrics, Enugu State University Teaching Hospital, Enugu, Nigeria.
Clin Med Insights Pediatr. 2017 Feb 16;11:1179556517690196. doi: 10.1177/1179556517690196. eCollection 2017.
The pattern of infant feeding during the first 1000-day period-from conception to the second birthday-has a significant influence on the child's growth trajectory. The relationship between exclusive breastfeeding and lower risk of childhood obesity has elicited much scientific interest, given the fact that this form of malnutrition is becoming a global epidemic.
This narrative review aims to examine the evidence in the literature linking exclusive breastfeeding with reduction in obesity in children.
Using appropriate search terms, PubMed database was searched for relevant articles that met the review objective.
Evidence for the protective effect of exclusive breastfeeding against childhood obesity have been provided by studies which explored 5 physiologic mechanisms and those that established the causality between breastfeeding and lower risk of obesity. The few studies that disputed this relationship highlighted the influence of confounding factors. A new insight on molecular mechanisms, however, points to a direct and indirect effect of human milk oligosaccharides on the prevention of overweight and obesity.
The preponderance of current evidence strongly suggests that exclusivity in breastfeeding can prevent the development of obesity in children.
从受孕到两岁的首个1000天期间的婴儿喂养模式对儿童的生长轨迹有重大影响。鉴于这种形式的营养不良正成为一种全球流行病,纯母乳喂养与儿童肥胖风险较低之间的关系引发了诸多科学关注。
本叙述性综述旨在审视文献中关于纯母乳喂养与儿童肥胖减少之间联系的证据。
使用适当的检索词,在PubMed数据库中搜索符合综述目标的相关文章。
探索了5种生理机制的研究以及确定了母乳喂养与较低肥胖风险之间因果关系的研究,都提供了纯母乳喂养对儿童肥胖具有保护作用的证据。少数对这种关系提出质疑的研究强调了混杂因素的影响。然而,关于分子机制的一项新见解指出,母乳中的低聚糖对预防超重和肥胖具有直接和间接作用。
目前的大量证据有力地表明,母乳喂养的排他性可预防儿童肥胖的发生。