Di Bonito Maria, Studer Michèle
Université Côte d'Azur, CNRS, Inserm, iBVNice, France.
Front Neural Circuits. 2017 Apr 19;11:18. doi: 10.3389/fncir.2017.00018. eCollection 2017.
During development, the organization of the auditory system into distinct functional subcircuits depends on the spatially and temporally ordered sequence of neuronal specification, differentiation, migration and connectivity. Regional patterning along the antero-posterior axis and neuronal subtype specification along the dorso-ventral axis intersect to determine proper neuronal fate and assembly of rhombomere-specific auditory subcircuits. By taking advantage of the increasing number of transgenic mouse lines, recent studies have expanded the knowledge of developmental mechanisms involved in the formation and refinement of the auditory system. Here, we summarize several findings dealing with the molecular and cellular mechanisms that underlie the assembly of central auditory subcircuits during mouse development, focusing primarily on the rhombomeric and dorso-ventral origin of auditory nuclei and their associated molecular genetic pathways.
在发育过程中，听觉系统组织成不同的功能亚回路取决于神经元特化、分化、迁移和连接的空间和时间有序序列。沿前后轴的区域模式形成与沿背腹轴的神经元亚型特化相互交叉，以确定正确的神经元命运和菱脑节特异性听觉亚回路的组装。利用越来越多的转基因小鼠品系，最近的研究扩展了我们对参与听觉系统形成和精细化的发育机制的认识。在这里，我们总结了一些关于小鼠发育过程中中枢听觉亚回路组装的分子和细胞机制的研究发现，主要关注听觉核团的菱脑节和背腹起源及其相关的分子遗传途径。
