Zhang Li, Xiang Feng-Gang, Wang Cheng-Qin
Department of Pathology, Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2017 Feb;26(1):64-68.
To investigate the expression and role of human Dachshund homolog1(DACH1)in the development and prognosis of tongue squamous cell carcinoma(TSCC).
The expression of DACH1 was detected immunohistochemistrically in 51 samples of paraffin-embedded TSCC, paired adjacent tissues and 25 samples of atypical hyperplasia tissues of the tongue. Statistical analysis was performed using SPSS 16.0 software package.
The results showed that 36 out of 51 TSCCs (70.6%) expressed lower levels of DACH1 compared with the paired adjacent tissues. Moreover, there was significant differences in expression of DACH1 between TSCC and paired adjacent tissues (P<0.05), and lower expression was associated with poor differentiation of tumors, advanced clinical stage and lymph node metastasis(P<0.05).In addition, the expression level of DACH1 in atypical hyperplasia tissues of tongue was also significantly lower than in tumors(P<0.05). Univariate survival analysis showed that the overall survival rate of patients with high expression of DACH1 was significantly higher than those with low expression of DACH1 (P<0.05).
The decreased expression of DACH1 may be related to occurrence, development and poor prognosis of TSCC. It may contribute to making diagnosis for precancerous lesions in the tongue, and provide a potential effective therapeutic target for TSCC.
探讨人类Dachshund同源物1（DACH1）在舌鳞状细胞癌（TSCC）发生发展及预后中的表达及作用。
采用免疫组织化学法检测51例石蜡包埋的TSCC标本、配对的癌旁组织以及25例舌非典型增生组织中DACH1的表达。使用SPSS 16.0软件包进行统计学分析。
结果显示，51例TSCC中有36例（70.6%）与配对的癌旁组织相比DACH1表达水平较低。此外，TSCC与配对的癌旁组织之间DACH1表达存在显著差异（P<0.05），且低表达与肿瘤低分化、临床晚期及淋巴结转移相关（P<0.05）。另外，舌非典型增生组织中DACH1的表达水平也显著低于肿瘤组织（P<0.05）。单因素生存分析显示，DACH1高表达患者的总生存率显著高于DACH1低表达患者（P<0.05）。
DACH1表达降低可能与TSCC的发生、发展及预后不良有关。它可能有助于舌癌前病变的诊断，并为TSCC提供潜在有效的治疗靶点。
