Kim Soo-Jeong, Shonka Sophia, French William P, Strickland Jennifer, Miller Lindsey, Stein Mark A
University of Washington, Seattle, WA, USA.
Seattle Children's Research Institute, Seattle, WA, USA.
J Autism Dev Disord. 2017 Aug;47(8):2307-2313. doi: 10.1007/s10803-017-3125-1.
Attention deficit/hyperactivity disorder (ADHD) symptoms are common in youth with autism spectrum disorders (ASD) and are frequently treated with stimulant medications. Twenty-seven children were randomized to different dose titration schedules, and ADHD symptoms, tolerability, and aberrant behaviors were assessed weekly during a 6-week trial with long-acting liquid methylphenidate (MPH). MPH at low to moderate doses was effective in reducing ADHD symptoms and was well tolerated in young children with ASD and ADHD. Future studies are needed to assess generalization and maintenance of efficacy.
注意缺陷/多动障碍（ADHD）症状在患有自闭症谱系障碍（ASD）的青少年中很常见，并且经常使用兴奋剂药物进行治疗。27名儿童被随机分配到不同的剂量滴定方案，在为期6周的长效液体哌甲酯（MPH）试验中，每周评估ADHD症状、耐受性和异常行为。低至中等剂量的MPH可有效减轻ADHD症状，并且在患有ASD和ADHD的幼儿中耐受性良好。未来需要进行研究以评估疗效的普遍性和持续性。
