Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Phone: +989032360639.
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar, Khuzestan, Iran.
J Basic Clin Physiol Pharmacol. 2020 Apr 23;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0191/jbcpp-2019-0191.xml. doi: 10.1515/jbcpp-2019-0191.
To date, a large number of synthetic drugs have been developed for the treatment and prevention of different disorders, such as neurodegenerative diseases, diabetes mellitus, and cancer. However, these drugs suffer from a variety of drawbacks including side effects and low efficacy. In response to this problem, researchers have focused on the plant-derived natural products due to their valuable biological activities and low side effects. Flavonoids consist of a wide range of naturally occurring compounds exclusively found in fruits and vegetables and demonstrate a number of pharmacological and therapeutic effects. Tangeretin (TGN) is a key member of flavonoids that is extensively found in citrus peels. It has different favorable biological activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. In the present review, we discuss the various pharmacological and therapeutic effects of TGN and then, demonstrate how this naturally occurring compound affects signaling pathways to exert its impacts.
迄今为止，已经开发出大量用于治疗和预防各种疾病的合成药物，如神经退行性疾病、糖尿病和癌症。然而，这些药物存在各种缺点，包括副作用和低疗效。针对这一问题，由于植物源性天然产物具有有价值的生物活性和低副作用，研究人员将注意力集中在它们身上。类黄酮是广泛存在于水果和蔬菜中的一类天然存在的化合物，具有多种药理和治疗作用。桔皮素（TGN）是类黄酮中的一个重要成员，在柑橘皮中广泛存在。它具有多种有利的生物活性，如抗氧化、抗炎、抗肿瘤、保肝和神经保护作用。在本综述中，我们讨论了 TGN 的各种药理和治疗作用，然后展示了这种天然存在的化合物如何影响信号通路来发挥其作用。
