Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun 130041, China.
Curr Neuropharmacol. 2018;16(1):17-28. doi: 10.2174/1570159X15666170504123316.
Epilepsy is a chronic brain disease that is caused by various factors and characterized by recurrent, episodic and temporary central nervous system dysfunction which results due to excessive discharge of brain neurons. In the past decades, despite the continuous development of antiepileptic drugs, there are still many patients with epilepsy progressing to drugresistant epilepsy. Currently, surgical treatment is one of important way to cure drug-resistant epilepsy.
Data were collected from Web of Science, Medline, Pubmed, through searching of these keywords: "surgery" and "drug-resistant epilepsy".
An increasing number of studies have shown that surgery plays an important role in the treatment of drug-resistant epilepsy. Moreover, the comprehensive treatment mainly based on surgery can achieve the remission and even cure of drug-resistant epilepsy.
In this review, we discuss the pathogenesis of drug-resistant epilepsy and the comprehensive treatment mainly based on surgery; this review may provide a reference for the clinical treatment of drug-resistant epilepsy.
癫痫是一种由多种因素引起的慢性脑部疾病，其特征是反复发作、间歇性和暂时性的中枢神经系统功能障碍，这是由于大脑神经元过度放电所致。在过去的几十年中，尽管抗癫痫药物不断发展，但仍有许多癫痫患者进展为难治性癫痫。目前，手术治疗是治疗耐药性癫痫的重要方法之一。
从 Web of Science、Medline、Pubmed 等数据库中收集数据，通过检索“手术”和“耐药性癫痫”等关键词进行检索。
越来越多的研究表明，手术在耐药性癫痫的治疗中起着重要作用。此外，以手术为主的综合治疗可以达到缓解甚至治愈耐药性癫痫的目的。
本文讨论了耐药性癫痫的发病机制和以手术为主的综合治疗；这篇综述可能为耐药性癫痫的临床治疗提供参考。
