Weber D A, Goering R V
Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Antimicrob Agents Chemother. 1988 Aug;32(8):1164-9. doi: 10.1128/AAC.32.8.1164.
We report the preliminary characterization of a 6.7-kilobase transposon, Tn4201, encoding resistance to penicillin associated with the conjugative plasmid pCRG1600 in Staphylococcus aureus. Tn4201 is capable of inverting in orientation (frequently observed in derivatives of pCRG1600) and is expressed equally well in either orientation. The element is also capable of movement to alternative plasmid and chromosomal sites. Tn4201 exhibits rec-independent transposition in an apparent site-specific manner and may play an important role in the resistance of staphylococci to beta-lactam compounds.
我们报告了一个6.7千碱基转座子Tn4201的初步特征，该转座子编码对青霉素的抗性，与金黄色葡萄球菌中的接合质粒pCRG1600相关。Tn4201能够反向（在pCRG1600的衍生物中经常观察到），并且在任何一种方向上都能同样良好地表达。该元件也能够转移到其他质粒和染色体位点。Tn4201以明显的位点特异性方式表现出不依赖rec的转座，并且可能 在葡萄球菌对β-内酰胺化合物的抗性中起重要作用。
