Lyon B R, May J W, Skurray R A
Mol Gen Genet. 1984;193(3):554-6. doi: 10.1007/BF00382099.
We describe a 4.5 kilobase transposon, Tn4001, which mediates resistance to gentamicin, tobramycin and kanamycin in Staphylococcus aureus. Originally detected in plasmid pSK1, Tn4001 was shown to undergo rec-independent transposition to the chromosome from this plasmid and from an inserted derivative of the plasmid pII147. Heteroduplexes between plasmids with and without Tn4001 demonstrated a characteristic stem and loop structure with inverted repeats of approx. 1.3 kilobases.
我们描述了一种4.5千碱基的转座子Tn4001，它介导金黄色葡萄球菌对庆大霉素、妥布霉素和卡那霉素的抗性。Tn4001最初在质粒pSK1中被检测到，已证明它能从该质粒以及质粒pII147的插入衍生物上进行不依赖于rec的转座至染色体。含有和不含有Tn4001的质粒之间的异源双链体显示出一种特征性的茎环结构，带有约1.3千碱基的反向重复序列。
