肥胖对肺转移瘤切除术后患者恶性肿瘤病程的影响。
Influence of Obesity on the Course of Malignant Neoplastic Disease in Patients After Pulmonary Metastasectomy.
作者信息
Rzechonek Adam, Błasiak Piotr, Pniewski Grzegorz, Cierpikowski Piotr, Mościbrodzka Monika, Ornat Maciej, Grzegrzółka Jędrzej, Brzecka Anna
机构信息
Department and Clinic of Thoracic Surgery, Wroclaw Medical University, Wroclaw, Poland
Department and Clinic of Thoracic Surgery, Wroclaw Medical University, Wroclaw, Poland.
出版信息
In Vivo. 2018 Jan-Feb;32(1):197-202. doi: 10.21873/invivo.11225.
BACKGROUND/AIM: The aim of the study was to determine whether increased body mass index (BMI) in patients operated on for lung metastases influences the course of the disease.
MATERIALS AND METHODS
The retrospective data of 97 patients previously operated on for different malignancies were analyzed. There were 40 obese patients (BMI >30 kg/m, mean 33.9±4.5) and 57 non-obese patients (BMI 25.8±2.7 kg/m, p<0.001). Disease-free interval (DFI), the overall survival (OS) and survival after pulmonary metastasectomy were analyzed.
RESULTS
DFI and OS were longer in obese than in non-obese patients (82.1±83.5 months vs. 43.0±44.4, p<0.01 and 110.7±81.3 months vs. 69.9±52.9 p<0.005, respectively). Survival after pulmonary metastasectomy was 27.2±25.6 months and was longer in obese and overweight patients than in normal weight patients (20.2±18.4 months vs. 29.4±26.5, p<0.05).
CONCLUSION
Being obese or overweight is a favorable prognostic factor in patients after surgical resection of lung metastases of different malignancies.
背景/目的：本研究旨在确定接受肺转移瘤手术患者的体重指数（BMI）升高是否会影响疾病进程。
材料与方法
分析了97例既往因不同恶性肿瘤接受手术患者的回顾性数据。其中有40例肥胖患者（BMI>30kg/m²，平均33.9±4.5）和57例非肥胖患者（BMI 25.8±2.7kg/m²，p<0.001）。分析了无病生存期（DFI）、总生存期（OS）以及肺转移瘤切除术后的生存期。
结果
肥胖患者的DFI和OS长于非肥胖患者（分别为82.1±83.5个月对43.0±44.4个月，p<0.01；110.7±81.3个月对69.9±52.9个月，p<0.005）。肺转移瘤切除术后的生存期为27.2±25.6个月，肥胖和超重患者的生存期长于正常体重患者（20.2±18.4个月对29.4±26.5个月，p<0.05）。
结论
肥胖或超重是不同恶性肿瘤肺转移瘤手术切除患者的有利预后因素。
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