Segeda V, Izakova L, Hlavacova N, Bednarova A, Jezova D
Department of Psychiatry, Faculty of Medicine, Comenius University and University Hospital Bratislava, Slovakia.
Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
J Psychiatr Res. 2017 Aug;91:164-168. doi: 10.1016/j.jpsychires.2017.04.011. Epub 2017 Apr 29.
Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the duration and severity of the depressive episode in a sex dependent manner. The sample consisted of 60 patients (37 postmenopausal women, 23 men) with major depressive disorder. Patients were examined two times, in acute depressive episode (admission to the hospital) and after reaching clinical remission (discharge). The samples of saliva were taken by the patients themselves twice a day (8.00-9.00 h in the morning and in the evening). Aldosterone concentrations were significantly higher in women compared to men and were significantly higher at the time of admission to the hospital compared to those at the discharge. Morning but not evening salivary aldosterone concentrations reflected the length of the depressive episode in women as well as the severity of the disorder in both sexes. Moreover, the patients with depression failed to exert known daily rhythmicity of aldosterone release. The present study brings several pieces of evidence suggesting the association of aldosterone with the pathophysiology of depression. Salivary aldosterone concentrations appear to reflect the outcome, the duration and the severity of the depressive episode in a sex dependent manner.
越来越多的证据表明，醛固酮可能发挥中枢作用并影响心理功能。本研究的目的是检验以下假设：重度抑郁症会影响唾液醛固酮的昼夜变化，且醛固酮浓度以性别依赖的方式反映抑郁发作的持续时间和严重程度。样本包括60名患有重度抑郁症的患者（37名绝经后女性，23名男性）。患者在急性抑郁发作期（入院时）和临床缓解后（出院时）接受了两次检查。唾液样本由患者本人每天采集两次（上午8:00 - 9:00和晚上）。女性的醛固酮浓度显著高于男性，且入院时的醛固酮浓度显著高于出院时。早晨而非晚上的唾液醛固酮浓度反映了女性抑郁发作的时长以及男女两性疾病的严重程度。此外，抑郁症患者未能表现出已知的醛固酮释放每日节律性。本研究提供了几条证据，表明醛固酮与抑郁症的病理生理学有关。唾液醛固酮浓度似乎以性别依赖的方式反映抑郁发作的结果、持续时间和严重程度。
