Flux Katharina
Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany; Labor für Dermatohistologie und Oralpathologie, Bayerstrasse 69, 80335 München, Munich, Germany.
Surg Pathol Clin. 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009.
Sebaceous skin tumors are classified into sebaceous adenoma, sebaceoma, and sebaceous carcinoma. An additional group of cystic sebaceous tumors indicate the Muir-Torre syndrome (MTS). Cystic sebaceous tumors are considered as morphologic variants of the 3 main categories. Multilineage adnexal tumors with partly sebaceous differentiation may pose a challenge to categorize. Sebaceous hyperplasia and nevus sebaceus are not considered as true sebaceous tumor entities. Recently, attention has been drawn to morphologic clues of sebaceous differentiation. Immunohistochemistry using the mismatch repair proteins and/or genetic microsatellite instability testing should be performed on sebaceous neoplasms to diagnose MTS as early as possible.
皮脂腺皮肤肿瘤分为皮脂腺腺瘤、皮脂腺瘤和皮脂腺癌。另一组囊性皮脂腺肿瘤提示穆尔-托里综合征（MTS）。囊性皮脂腺肿瘤被认为是3种主要类型的形态学变异。具有部分皮脂腺分化的多谱系附属器肿瘤在分类上可能具有挑战性。皮脂腺增生和皮脂腺痣不被视为真正的皮脂腺肿瘤实体。最近，人们已将注意力转向皮脂腺分化的形态学线索。应对皮脂腺肿瘤进行错配修复蛋白免疫组化和/或基因微卫星不稳定性检测，以便尽早诊断MTS。
