蛋白磷酸酶对心脏间隙连接的调节
Regulation of cardiac gap junctions by protein phosphatases.
作者信息
Hood Ashleigh R, Ai Xun, Pogwizd Steven M
机构信息
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.
Department of Biophysics and Physiology, Rush University, Chicago, IL, United States.
出版信息
J Mol Cell Cardiol. 2017 Jun;107:52-57. doi: 10.1016/j.yjmcc.2017.05.002. Epub 2017 May 3.
Abstract
Sufficient connexin-mediated intercellular coupling is critical to maintain gap junctional communication for proper cardiac function. Alterations in connexin phosphorylation state, particularly dephosphorylation of connexin 43 (Cx43), may impact cell coupling and conduction in disease states. Cx43 dephosphorylation may be carried out by protein phosphatase activity. Here, we present an overview of the key phosphatases known to interact with Cx43 or modulators of Cx43, as well as some possible therapeutic targets to regulate phosphatase activity in the heart.
摘要
足够的连接蛋白介导的细胞间偶联对于维持间隙连接通讯以实现正常心脏功能至关重要。连接蛋白磷酸化状态的改变，尤其是连接蛋白43（Cx43）的去磷酸化，可能会在疾病状态下影响细胞偶联和传导。Cx43去磷酸化可能由蛋白磷酸酶活性来完成。在此，我们概述了已知与Cx43相互作用的关键磷酸酶或Cx43调节剂，以及一些调节心脏中磷酸酶活性的可能治疗靶点。
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